Epigenetic modifications in solid tumor metastasis in people of African ancestry.

Autor:	Oladipo EK; Genomics Unit, Helix Biogen Institute, Ogbomoso, Oyo, Nigeria.; Laboratory of Molecular Biology, Immunology and Bioinformatics, Adeleke University, Ede, Osun State, Nigeria., Olufemi SE; Genomics Unit, Helix Biogen Institute, Ogbomoso, Oyo, Nigeria.; Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo, Nigeria., Adediran DA; Genomics Unit, Helix Biogen Institute, Ogbomoso, Oyo, Nigeria.; Department of Biochemistry, Ladoke Akintola University of Technology, Ogbomoso, Oyo, Nigeria., Adejumo IO; Genomics Unit, Helix Biogen Institute, Ogbomoso, Oyo, Nigeria., Jimah EM; Genomics Unit, Helix Biogen Institute, Ogbomoso, Oyo, Nigeria., Oloke JK; Genomics Unit, Helix Biogen Institute, Ogbomoso, Oyo, Nigeria.; Department of Natural Sciences, Precious Cornerstone University, Ibadan, Nigeria., Udekwu CC; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, United States., Ogunwobi OO; Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in oncology [Front Oncol] 2024 Feb 21; Vol. 14, pp. 1325614. Date of Electronic Publication: 2024 Feb 21 (Print Publication: 2024).
DOI:	10.3389/fonc.2024.1325614
Abstrakt:	This review focuses on the critical role of epigenetic modifications in solid tumor metastasis, particularly in people of African ancestry. Epigenetic alterations, such as DNA methylation, histone modifications, alterations in non-coding RNAs, and mRNA methylation, significantly influence gene expression, contributing to cancer development and progression. Despite the primary focus on populations of European, American, and Asian descent in most cancer research, this work emphasizes the importance of studying the unique genetic and epigenetic landscapes of African populations for a more inclusive approach in understanding and treating cancer. Insights from this review have the potential to pave the way for the development of effective, tailored treatments, and provide a richer resource for understanding cancer progression and metastasis. Specific focus was placed on the role of DNA methylation, histone modifications, non-coding RNAs, and mRNA methylation in solid tumor metastasis, including how these modifications contribute to the regulation of tumor suppressor genes and oncogenes, influence cellular pathways and signaling, and interact with the immune system. Moreover, this review elaborates on the development of epigenetic-targeted therapeutic strategies and the current advances in this field, highlighting the promising applications of these therapies in improving outcomes for African ancestry populations disproportionately affected by certain types of cancer. Nevertheless, this work acknowledges the challenges that lie ahead, particularly the under-representation of African populations in cancer genomic and epigenomic studies and the technical complications associated with detecting subtle epigenetic modifications. Emphasis is placed on the necessity for more inclusive research practices, the development of more robust and sensitive methods for detecting and interpreting epigenetic changes, and the understanding of the interplay between genetic and epigenetic variations. The review concludes with an optimistic outlook on the future of epigenetic research in People of African ancestry, urging the concerted efforts of researchers, clinicians, funding agencies, and policymakers to extend the benefits of this research to all populations. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Oladipo, Olufemi, Adediran, Adejumo, Jimah, Oloke, Udekwu and Ogunwobi.)
Databáze:	MEDLINE
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