How mitochondrial cristae illuminate the important role of oxygen during eukaryogenesis.

Autor: Speijer D; Medical Biochemistry, Amsterdam UMC location, University of Amsterdam, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: BioEssays : news and reviews in molecular, cellular and developmental biology [Bioessays] 2024 May; Vol. 46 (5), pp. e2300193. Date of Electronic Publication: 2024 Mar 06.
DOI: 10.1002/bies.202300193
Abstrakt: Inner membranes of mitochondria are extensively folded, forming cristae. The observed overall correlation between efficient eukaryotic ATP generation and the area of internal mitochondrial inner membranes both in unicellular organisms and metazoan tissues seems to explain why they evolved. However, the crucial use of molecular oxygen (O 2 ) as final acceptor of the electron transport chain is still not sufficiently appreciated. O 2 was an essential prerequisite for cristae development during early eukaryogenesis and could be the factor allowing cristae retention upon loss of mitochondrial ATP generation. Here I analyze illuminating bacterial and unicellular eukaryotic examples. I also discuss formative influences of intracellular O 2 consumption on the evolution of the last eukaryotic common ancestor (LECA). These considerations bring about an explanation for the many genes coming from other organisms than the archaeon and bacterium merging at the start of eukaryogenesis.
(© 2024 The Authors. BioEssays published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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