Low physical function following cancer diagnosis is associated with higher mortality risk in postmenopausal women.

Autor:	Gonzalo-Encabo P; Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Facultad de Medicina y Ciencias de la Salud, Departamento de Ciencias Biomédicas, Área de Educación Física y Deportiva, Universidad de Alcalá, Madrid, Spain., Vasbinder A; Department of Biobehavioral Nursing and Health Informatics, University of Washington School of Nursing, Seattle, WA, USA., Bea JW; Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA., Reding KW; Department of Biobehavioral Nursing and Health Informatics, University of Washington School of Nursing, Seattle, WA, USA., Laddu D; Arbor Research Collaborative for Health, Ann Arbor, MI, USA., LaMonte MJ; Department of Epidemiology and Environmental Health, University at Buffalo, Buffalo, NY, USA., Stefanick ML; Stanford Medicine, Stanford Prevention Research Center, Stanford University, CA, USA., Kroenke CH; Kaiser Permanente Northern California Division of Research, Oakland, CA, USA.; Kaiser Permanente School of Medicine, Pasadena, CA, USA., Jung SY; Department of Epidemiology, Fielding School of Public Health, Translational Sciences Section, School of Nursing, Jonsson Comprehensive Cancer Center, University of California Lost Angeles, Los Angeles, CA, USA., Shadyab AH; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, USA., Naughton MJ; Division of Cancer Prevention & Control, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA., Patel MI; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA., Luo J; Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN, USA., Banack HR; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Sun Y; Department of Preventive Medicine, The University of Tennessee Health Science Center, Memphis, TN, USA., Simon MS; Department of Oncology, Karmanos Cancer Institute at Wayne State University, Detroit, MI, USA., Dieli-Conwright CM; Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.
Jazyk:	angličtina
Zdroj:	Journal of the National Cancer Institute [J Natl Cancer Inst] 2024 Jul 01; Vol. 116 (7), pp. 1035-1042.
DOI:	10.1093/jnci/djae055
Abstrakt:	Background: Postmenopausal women with cancer experience an accelerated physical dysfunction beyond what is expected through aging alone due to cancer and its treatments. The aim of this study was to determine whether declines in physical function after cancer diagnosis are associated with all-cause mortality and cancer-specific mortality. Methods: This prospective cohort study included 8068 postmenopausal women enrolled in the Women's Health Initiative with a cancer diagnosis and who had physical function assessed within 1 year of that diagnosis. Self-reported physical function was measured using the 10-item physical function subscale of the 36-Item Short Form Health Survey. Cause of death was determined by medical record review, with central adjudication and linkage to the National Death Index. Death was adjudicated through February 2022. Results: Over a median follow-up of 7.7 years from cancer diagnosis, 3316 (41.1%) women died. Our results showed that for every 10% difference in the physical function score after cancer diagnosis versus pre-diagnosis, all-cause mortality and cancer-specific mortality were reduced by 12% (hazard ratio [HR] = 0.88, 95% confidence interval  [95% CI] = 0.87 to 0.89 and HR = 0.88, 95% CI = 0.86 to 0.91, respectively). Further categorical analyses showed a significant dose-response relationship between postdiagnosis physical function categories and mortality outcomes (P < .001 for trend), where the median survival time for women in the lowest physical function quartile was 9.1 years (Interquartile range [IQR] = 8.6-10.6 years) compared with 18.4 years (IQR = 15.8-22.0 years) for women in the highest physical function quartile. Conclusion: Postmenopausal women with low physical function after cancer diagnosis may be at higher risk of mortality from all causes and cancer-related mortality. (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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