SNP-based and haplotype-based genome-wide association on drug dependence in Han Chinese.

Autor: Xu H; College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing, 100028, China., Kang Y; Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. kangyulin@craes.org.cn., Liang T; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, School of Life Science, Nanjing Normal University, Nanjing, 210023, China., Lu S; Precision Medicine Key Laboratory of Sichuan Province and Precision Medicine Center, West China Hospital, Sichuan University, Chengdu, 610041, China., Xia X; Office of Academic Affairs, The National Police University for Criminal Justice, Baoding, 071000, China., Lu Z; School of Biological Science & Medical Engineering, Southeast University, Nanjing, 211189, China., Hu L; Chinese Research Academy of Environmental Sciences, Beijing, 100012, China., Guo L; School of Geographic and Biologic Information, Nanjing University of Posts and Telecommunications, Nanjing, 210003, China., Zhang L; College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing, 100028, China., Huang J; College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing, 100028, China., Ye L; Cheung Hong School of Journalism and Communication, Shantou University, Shantou, 515060, China., Jiang P; Office of International Cooperation and Exchanges, Nanjing University, Nanjing, 210023, China., Liu Y; Jiangsu Taihu Institute of Addiction Rehabilitation, Suzhou, 215111, China., Xinyi L; College of Life Sciences and Bioengineering, School of Science, Beijing Jiaotong University, Beijing, 100028, China., Zhai J; Department of Social Work, Changzhou University, Changzhou, 213164, China., Wang Z; School of Music, Nanjing Normal University, Nanjing, 210097, China., Liu Y; Department of Psychology, Nanjing University, Nanjing, 210023, China. liuyangyang661@sina.com.; School of Education, Tianjin University, Tianjin, 200350, China. liuyangyang661@sina.com.
Jazyk: angličtina
Zdroj: BMC genomics [BMC Genomics] 2024 Mar 06; Vol. 25 (1), pp. 255. Date of Electronic Publication: 2024 Mar 06.
DOI: 10.1186/s12864-024-10117-4
Abstrakt: Background: Drug addiction is a serious problem worldwide and is influenced by genetic factors. The present study aimed to investigate the association between genetics and drug addiction among Han Chinese.
Methods: A total of 1000 Chinese users of illicit drugs and 9693 healthy controls were enrolled and underwent single nucleotide polymorphism (SNP)-based and haplotype-based association analyses via whole-genome genotyping.
Results: Both single-SNP and haplotype tests revealed associations between illicit drug use and several immune-related genes in the major histocompatibility complex (MHC) region (SNP association: log 10 BF = 15.135, p = 1.054e-18; haplotype association: log 10 BF = 20.925, p = 2.065e-24). These genes may affect the risk of drug addiction via modulation of the neuroimmune system. The single-SNP test exclusively reported genome-wide significant associations between rs3782886 (SNP association: log 10 BF = 8.726, p = 4.842e-11) in BRAP and rs671 (SNP association: log 10 BF = 7.406, p = 9.333e-10) in ALDH2 and drug addiction. The haplotype test exclusively reported a genome-wide significant association (haplotype association: log 10 BF = 7.607, p = 3.342e-11) between a region with allelic heterogeneity on chromosome 22 and drug addiction, which may be involved in the pathway of vitamin B12 transport and metabolism, indicating a causal link between lower vitamin B12 levels and methamphetamine addiction.
Conclusions: These findings provide new insights into risk-modeling and the prevention and treatment of methamphetamine and heroin dependence, which may further contribute to potential novel therapeutic approaches.
(© 2024. The Author(s).)
Databáze: MEDLINE
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