Genetics of chronic respiratory disease.

Autor: Sayers I; NIHR Nottingham Biomedical Research Centre, University of Nottingham, University Park, Nottingham, UK.; Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, UK., John C; University of Leicester, Leicester, UK.; University Hospitals of Leicester, Leicester, UK., Chen J; University of Leicester, Leicester, UK., Hall IP; NIHR Nottingham Biomedical Research Centre, University of Nottingham, University Park, Nottingham, UK. ian.hall@nottingham.ac.uk.; Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, UK. ian.hall@nottingham.ac.uk.
Jazyk: angličtina
Zdroj: Nature reviews. Genetics [Nat Rev Genet] 2024 Aug; Vol. 25 (8), pp. 534-547. Date of Electronic Publication: 2024 Mar 06.
DOI: 10.1038/s41576-024-00695-0
Abstrakt: Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD), asthma and interstitial lung diseases are frequently occurring disorders with a polygenic basis that account for a large global burden of morbidity and mortality. Recent large-scale genetic epidemiology studies have identified associations between genetic variation and individual respiratory diseases and linked specific genetic variants to quantitative traits related to lung function. These associations have improved our understanding of the genetic basis and mechanisms underlying common lung diseases. Moreover, examining the overlap between genetic associations of different respiratory conditions, along with evidence for gene-environment interactions, has yielded additional biological insights into affected molecular pathways. This genetic information could inform the assessment of respiratory disease risk and contribute to stratified treatment approaches.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
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