Two-Year Clinical Outcome of MitraClip Transcatheter Edge-to-Edge Repair From the J-MITRA Registry Data.

Autor:	Imamura T; Second Department of Internal Medicine, University of Toyama., Nakai M; Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center.; Clinical Research Support Center, University of Miyazaki Hospital., Iwanaga Y; Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center.; Department of Cardiology, Sakurabashi-Watanabe Hospital., Sumita Y; Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center., Tao M; Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center., Ohno Y; Division of Cardiology, Department of Internal Medicine, Tokai University School of Medicine., Hayashida K; Department of Cardiology, Keio University School of Medicine., Morino Y; Division of Cardiology, Department of Internal Medicine, Iwate Medical University., Seo Y; Department of Cardiology, Nagoya City University Graduate School of Medical Sciences., Saiki Y; Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine., Anzai T; Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University., Toda K; Department of Cardiovascular Surgery, Dokkyo Medical University Saitama Medical Center., Matsumiya G; Department of Cardiovascular Surgery, Chiba University Graduate School of Medicine., Yamamoto K; Division of Cardiovascular Medicine and Endocrinology and Metabolism, Faculty of Medicine, Tottori University., Hirata K; Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine., Kinugawa K; Second Department of Internal Medicine, University of Toyama.
Jazyk:	angličtina
Zdroj:	Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2024 Mar 25; Vol. 88 (4), pp. 539-548. Date of Electronic Publication: 2024 Mar 06.
DOI:	10.1253/circj.CJ-23-0924
Abstrakt:	Background: The introduction of transcatheter edge-to-edge repair for moderate-to-severe or severe mitral regurgitation (MR) utilizing the MitraClip system became reimbursed and clinically accessible in Japan in April 2018. This study presents the 2-year clinical outcomes of all consecutively treated patients who underwent MitraClip implantation in Japan and were prospectively enrolled in the Japanese Circulation Society-oriented J-MITRA registry. Methods and results: Analysis encompassed 2,739 consecutive patients enrolled in the J-MITRA registry with informed consent (mean age: 78.3±9.6 years, 1,550 males, STS risk score 11.7±8.9), comprising 1,999 cases of functional MR, 644 of degenerative MR and 96 in a mixed group (DMR and FMR). The acute procedure success rate was 88.9%. After MitraClip implantation, >80% exhibited an MR grade ≤2+ and the trend was sustained over the 2 years. Within this observation period, the mortality rate was 19.3% and the rate of heart failure readmissions was 20.6%. The primary composite endpoint, inclusive of cardiovascular death and heart failure readmission, was significantly higher in patients with functional MR than in with degenerative MR (32.0% vs. 17.5%, P<0.001). Conclusions: The 2-year clinical outcomes after MitraClip implantation were deduced from comprehensive data within an all-Japan registry.
Databáze:	MEDLINE
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