Sofosbuvir (+) daclatasvir (+) ribavirin in Egyptian patients with hepatitis C virus: Therapeutic outcomes and the prognostic role of natural killer cells.

Autor: Zaid AB; Department of Clinical Pathology, National Liver Institute, Menoufia University, Shibin Elkom 32511, Egypt., Almady SK; Department of Hepatology and Gastroenterology, National Liver Institute, Menoufia University, Shibin-Elkom 32511, Egypt., Awad SM; Department of Clinical Microbiology, National Liver Institute, Menoufia University, Shibin Elkom 32511, Egypt., Elabd MG; Department of Clinical Pathology, National Liver Institute, Menoufia University, Shibin Elkom 32511, Egypt., Saied SA; Department of Clinical Pathology, National Liver Institute, Menoufia University, Shibin Elkom 32511, Egypt., Saied AA; Ministry of Tourism and Antiquities, Aswan Office, Aswan 81511, Egypt., Elmalawany AM; Department of Clinical Pathology, National Liver Institute, Menoufia University, Shibin Elkom 32511, Egypt. Electronic address: smalawany@liver.menofia.edu.eg.
Jazyk: angličtina
Zdroj: Current research in translational medicine [Curr Res Transl Med] 2024 Sep; Vol. 72 (3), pp. 103443. Date of Electronic Publication: 2024 Mar 01.
DOI: 10.1016/j.retram.2024.103443
Abstrakt: Background: One of the prominent causes of chronic liver disease worldwide is the hepatitis C virus (HCV). HCV believed that innate immunity contributes to a sustained virological response (SVR) to the treatment of Sofosbuvir (SOF) (+) Daclatasvir (DCV) (+) Ribavirin (RBV). This study aimed to evaluate the impact of SOF (+) DCV (+) RBV therapy and persistent HCV infection on the subset of natural killer cells (NK) in HCV genotype four patients from Egypt.
Materials and Methods: One hundred and ten patients with persistent HCV infections requiring SOF (+) DCV (+) RBV therapy were grouped, and a flow cytometry (FCM) study of the NK cell subset in peripheral blood was performed. The assessment was performed before and after three and/or six months of the cessation of viral suppression therapy when a patient had a long-term viral response (SVR). One hundred and ten volunteers from the National Liver Institute ' s (NLI) blood bank were selected as controls.
Results: Patients with chronic HCV infection before therapy had considerably lower CD16 + and CD3 - CD56 + cells than controls. Their levels increase during SOF (+) DCV (+) RBV therapy. In patients with SVR during treatment, CD16 + and CD3 - CD56 + cells increased significantly compared to those who did not get SVR. Furthermore, CD56 + cells were significantly higher in patients with persistent infection before treatment than controls but diminished with the response to treatment.
Conclusion: NK cell activation following SOF (+) DCV (+) RBV therapy and polarization to cytotoxicity occurred early in HCV antiviral therapy and was elevated in the respondents. Our data illustrated that establishing an inhibitory cytotoxic NK profile is related to therapeutic outcomes.
(Copyright © 2024. Published by Elsevier Masson SAS.)
Databáze: MEDLINE
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