Keratosis pilaris treatment paradigms: assessing effectiveness across modalities.

Autor:	Wong PC; Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Wang MA; Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia., Ng TJ; Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia., Akbarialiabad H; Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.; Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia., Murrell DF; Faculty of Medicine and Health, University of New South Wales, Sydney, NSW, Australia.; Department of Dermatology, St George Hospital, University of New South Wales, Sydney, NSW, Australia.; The George Institute for Global Health, Sydney, NSW, Australia.
Jazyk:	angličtina
Zdroj:	Clinical and experimental dermatology [Clin Exp Dermatol] 2024 Sep 18; Vol. 49 (10), pp. 1105-1117.
DOI:	10.1093/ced/llae066
Abstrakt:	This review aims to present a comprehensive synthesis of the existing treatment modalities for keratosis pilaris (KP) and evaluate their therapeutic efficacy. KP is a prevalent chronic dermatological condition typified by its unique 'chicken skin appearance', with the cheeks being the most commonly involved sites. Numerous therapeutic interventions have emerged, given its substantial prevalence and impact on skin aesthetics and psychological wellbeing. Nonetheless, a consistent therapeutic response has been challenging to achieve. This review endeavours to collate and critically appraise the current treatment landscape for KP. An exhaustive literature search was performed using databases such as Ovid, PubMed and Scopus. From an initial count of 459 articles identified after deduplication, 52 were selected for inclusion after a thorough full-text examination for articles with concrete outcome data highlighting the efficacies of different therapeutic modalities; articles that lacked data or were tangential to the core focus on KP treatment were excluded. The included articles were then catalogued based on the nature of treatment strategies and their respective outcomes. Among the various therapeutic interventions, laser and light modalities appear to be supported by the most substantial evidence base. Notably, the Nd:YAG (neodymium-doped yttrium-aluminium-garnet) laser, attributed to its longer wavelength, emerged as a preferred option. While other therapeutic avenues have also exhibited notable improvements in skin texture and discolouration relative to baseline, the inconsistency in outcome measures underscores the need for a standardized, KP-specific scoring system to foster a more coherent comparison across treatments. Based on the current evidence, Nd:YAG laser therapy demonstrates promising effectiveness with a relatively favourable side-effect profile. However, the landscape of KP treatment is multifaceted, and further studies are essential to solidify recommendations. Competing Interests: Conflicts of interest The authors declare no conflicts of interest. (© The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)
Databáze:	MEDLINE
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