Perioperative management and clinical outcomes of peristomal pyoderma gangrenosum.

Autor: Becker SL; Department of Dermatology, Oregon Health and Science University, 3303 S Bond Ave Building 1, 16th Floor, Portland, OR, 97239, USA. beckersa@ohsu.edu., Rios-Duarte JA; School of Medicine, Universidad de los Andes, Bogotá D.C., Colombia., Morrison GM; Department of Dermatology, Oregon Health and Science University, 3303 S Bond Ave Building 1, 16th Floor, Portland, OR, 97239, USA., Xia E; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Boston University School of Medicine, Boston, MA, USA., Mostaghimi A; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Himed S; Department of Dermatology, The Ohio State University, Columbus, OH, USA., Kaffenberger BH; Department of Dermatology, The Ohio State University, Columbus, OH, USA., Zhang D; University of Wisconsin, Madison, WI, USA., Shields BE; University of Wisconsin, Madison, WI, USA., Cogen AL; University of Washington, Seattle, WA, USA., Ortega-Loayza AG; Department of Dermatology, Oregon Health and Science University, 3303 S Bond Ave Building 1, 16th Floor, Portland, OR, 97239, USA.
Jazyk: angličtina
Zdroj: Archives of dermatological research [Arch Dermatol Res] 2024 Mar 06; Vol. 316 (4), pp. 98. Date of Electronic Publication: 2024 Mar 06.
DOI: 10.1007/s00403-024-02826-3
Abstrakt: Peristomal pyoderma gangrenosum is an uncommon subtype of pyoderma gangrenosum mainly affecting stoma sites of patients with inflammatory bowel disease. While surgical treatments are often used to assist healing, little is known about the relationship between surgical interventions and the rate of recurrence of peristomal pyoderma gangrenosum. The aim of this study was to identify patient and clinical factors associated with peristomal pyoderma gangrenosum recurrence following surgical intervention. A multi-institutional retrospective case series and literature review was conducted to evaluate patient characteristics and perioperative treatment. Patients of any age with peristomal pyoderma gangrenosum undergoing surgical operations related to their pyoderma gangrenosum or due to another comorbidity were included. Descriptive statistics were used to characterize demographic information. Associations were evaluated using Wilcoxon's rank-sum test for continuous variables and Fisher's exact test for categorical data. Thirty-seven cases were included, 78.3% of which had a history of inflammatory bowel disease. Overall, 13 (35.1%) cases experienced recurrence at 30 days. There was no significant association identified between patient demographics, stoma location, surgical intervention, or perioperative treatment with rate of recurrence at 30 days post-operation. While no clinical risk factors or treatments were associated with recurrence, our work underscores the importance of a multidisciplinary approach to this disease to address gastrointestinal, dermatologic, and surgical components of treatment.
(© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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