Between neurons and networks: investigating mesoscale brain connectivity in neurological and psychiatric disorders.

Autor:	Caznok Silveira AC; National Laboratory of Biosciences, Brazilian Center for Research in Energy and Materials, Campinas, Brazil.; School of Electrical and Computer Engineering, University of Campinas, Campinas, Brazil., Antunes ASLM; National Laboratory of Biosciences, Brazilian Center for Research in Energy and Materials, Campinas, Brazil., Athié MCP; National Laboratory of Biosciences, Brazilian Center for Research in Energy and Materials, Campinas, Brazil., da Silva BF; National Laboratory of Biosciences, Brazilian Center for Research in Energy and Materials, Campinas, Brazil., Ribeiro Dos Santos JV; National Laboratory of Biosciences, Brazilian Center for Research in Energy and Materials, Campinas, Brazil., Canateli C; National Laboratory of Biosciences, Brazilian Center for Research in Energy and Materials, Campinas, Brazil., Fontoura MA; National Laboratory of Biosciences, Brazilian Center for Research in Energy and Materials, Campinas, Brazil., Pinto A; Brazilian Synchrotron Light Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, Brazil., Pimentel-Silva LR; Neuroimaging Laboratory, Neurology Department, University of Campinas, School of Medical Sciences, Campinas, Brazil., Avansini SH; National Laboratory of Biosciences, Brazilian Center for Research in Energy and Materials, Campinas, Brazil., de Carvalho M; National Laboratory of Biosciences, Brazilian Center for Research in Energy and Materials, Campinas, Brazil.; Brazilian Synchrotron Light Laboratory, Brazilian Center for Research in Energy and Materials, Campinas, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2024 Feb 20; Vol. 18, pp. 1340345. Date of Electronic Publication: 2024 Feb 20 (Print Publication: 2024).
DOI:	10.3389/fnins.2024.1340345
Abstrakt:	The study of brain connectivity has been a cornerstone in understanding the complexities of neurological and psychiatric disorders. It has provided invaluable insights into the functional architecture of the brain and how it is perturbed in disorders. However, a persistent challenge has been achieving the proper spatial resolution, and developing computational algorithms to address biological questions at the multi-cellular level, a scale often referred to as the mesoscale. Historically, neuroimaging studies of brain connectivity have predominantly focused on the macroscale, providing insights into inter-regional brain connections but often falling short of resolving the intricacies of neural circuitry at the cellular or mesoscale level. This limitation has hindered our ability to fully comprehend the underlying mechanisms of neurological and psychiatric disorders and to develop targeted interventions. In light of this issue, our review manuscript seeks to bridge this critical gap by delving into the domain of mesoscale neuroimaging. We aim to provide a comprehensive overview of conditions affected by aberrant neural connections, image acquisition techniques, feature extraction, and data analysis methods that are specifically tailored to the mesoscale. We further delineate the potential of brain connectivity research to elucidate complex biological questions, with a particular focus on schizophrenia and epilepsy. This review encompasses topics such as dendritic spine quantification, single neuron morphology, and brain region connectivity. We aim to showcase the applicability and significance of mesoscale neuroimaging techniques in the field of neuroscience, highlighting their potential for gaining insights into the complexities of neurological and psychiatric disorders. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Caznok Silveira, Antunes, Athié, da Silva, Ribeiro dos Santos, Canateli, Fontoura, Pinto, Pimentel-Silva, Avansini and de Carvalho.)
Databáze:	MEDLINE
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