Outcome of transarterial radioembolization in patients with hepatocellular carcinoma as a first-line interventional therapy and after a previous transarterial chemoembolization.

Autor:	Wagenpfeil J; Department of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, Germany.; Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Germany., Kupczyk PA; Department of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, Germany.; Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Germany., Bruners P; Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Germany.; Department of Diagnostic and Interventional Radiology, University Hospital of Aachen, Aachen, Germany., Siepmann R; Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Germany.; Department of Diagnostic and Interventional Radiology, University Hospital of Aachen, Aachen, Germany., Guendel E; Department of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, Germany.; Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Germany., Luetkens JA; Department of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, Germany.; Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Germany., Isaak A; Department of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, Germany.; Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Germany., Meyer C; Department of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, Germany.; Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Germany., Kuetting F; Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Germany., Pieper CC; Department of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, Germany.; Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Germany., Attenberger UI; Department of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, Germany.; Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Germany., Kuetting D; Department of Diagnostic and Interventional Radiology, University Hospital of Bonn, Bonn, Germany.; Center for Integrated Oncology (CIO), Aachen-Bonn-Cologne-Duesseldorf, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in radiology [Front Radiol] 2024 Feb 20; Vol. 4, pp. 1346550. Date of Electronic Publication: 2024 Feb 20 (Print Publication: 2024).
DOI:	10.3389/fradi.2024.1346550
Abstrakt:	Purpose: Due to a lack of data, there is an ongoing debate regarding the optimal frontline interventional therapy for unresectable hepatocellular carcinoma (HCC). The aim of the study is to compare the results of transarterial radioembolization (TARE) as the first-line therapy and as a subsequent therapy following prior transarterial chemoembolization (TACE) in these patients. Methods: A total of 83 patients were evaluated, with 38 patients having undergone at least one TACE session prior to TARE [27 male; mean age 67.2 years; 68.4% stage Barcelona clinic liver cancer (BCLC) B, 31.6% BCLC C]; 45 patients underwent primary TARE (33 male; mean age 69.9 years; 40% BCLC B, 58% BCLC C). Clinical [age, gender, BCLC stage, activity in gigabecquerel (GBq), Child-Pugh status, portal vein thrombosis, tumor volume] and procedural [overall survival (OS), local tumor control (LTC), and progression-free survival (PFS)] data were compared. A regression analysis was performed to evaluate OS, LTC, and PFS. Results: No differences were found in OS (95% CI: 1.12, P  = 0.289), LTC (95% CI: 0.003, P  = 0.95), and PFS (95% CI: 0.4, P  = 0.525). The regression analysis revealed a relationship between Child-Pugh score ( P  = 0.005), size of HCC lesions (>10 cm) ( P  = 0.022), and OS; neither prior TACE (Child-Pugh B patients; 95% CI: 0.120, P  = 0.729) nor number of lesions (>10; 95% CI: 2.930, P  = 0.087) correlated with OS. Conclusion: Prior TACE does not affect the outcome of TARE in unresectable HCC. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2024 Wagenpfeil, Kupczyk, Bruners, Siepmann, Guendel, Luetkens, Isaak, Meyer, Kuetting, Pieper, Attenberger and Kuetting.)
Databáze:	MEDLINE
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