Real-world walking cadence in people with COPD.

Autor:	Delgado-Ortiz L; ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., Ranciati S; Department of Statistical Sciences, Università di Bologna, Bologna, Italy., Arbillaga-Etxarri A; Deusto Physical TherapIker, Physical Therapy Department, Faculty of Health Sciences, University of Deusto, San Sebastian, Spain., Balcells E; Universitat Pompeu Fabra, Barcelona, Spain.; Respiratory Medicine Department, Hospital del Mar, Barcelona, Spain.; Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Instituto de Salud Carlos III, Barcelona, Spain.; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain., Buekers J; ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain., Demeyer H; Department of Rehabilitation Sciences, KULeuven, Leuven, Belgium.; Department of Rehabilitation Sciences, Ghent University, Ghent, Belgium., Frei A; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland., Gimeno-Santos E; ISGlobal, Barcelona, Spain.; Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Instituto de Salud Carlos III, Barcelona, Spain.; Hospital Clínic de Barcelona, Barcelona, Spain., Hopkinson NS; National Heart and Lung Institute, Imperial College London, London, UK., de Jong C; Groningen Research Institute for Asthma and COPD, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands., Karlsson N; BioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden., Louvaris Z; Department of Rehabilitation Sciences, KULeuven, Leuven, Belgium., Palmerini L; Department of Electrical, Electronic, and Information Engineering 'Guglielmo Marconi', Università di Bologna, Bologna, Italy., Polkey MI; National Heart and Lung Institute, Imperial College London, London, UK.; Respiratory Medicine, Royal Brompton and Harefield NHS Foundation Trust, London, UK., Puhan MA; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland., Rabinovich RA; Respiratory Medicine Department, Royal Infirmary of Edinburgh, Centre for Inflammation Research, QMRI, The University of Edinburgh, Scotland, UK., Rodríguez Chiaradia DA; Respiratory Medicine Department, Hospital del Mar, Barcelona, Spain.; Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Instituto de Salud Carlos III, Barcelona, Spain.; Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain., Rodriguez-Roisin R; Biomedical Research Networking Centre on Respiratory Diseases (CIBERES), Instituto de Salud Carlos III, Barcelona, Spain.; Universitat de Barcelona, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic of Barcelona, Barcelona, Spain., Toran-Montserrat P; Unitat de Suport a la Recerca Metropolitana Nord, Institut Universitari d'Investigació en Atenció Primària Jordi Gol, Mataró, Spain.; Germans Trias i Pujol Research Institute, Badalona, Spain., Vogiatzis I; Department of Sport, Exercise and Rehabilitation, Northumbria University Newcastle, Newcastle upon Tyne, UK., Watz H; Pulmonary Research Institute at Lungen Clinic Grosshansdorf, Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany., Troosters T; Department of Rehabilitation Sciences, KULeuven, Leuven, Belgium., Garcia-Aymerich J; ISGlobal, Barcelona, Spain.; Universitat Pompeu Fabra, Barcelona, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.
Jazyk:	angličtina
Zdroj:	ERJ open research [ERJ Open Res] 2024 Mar 04; Vol. 10 (2). Date of Electronic Publication: 2024 Mar 04 (Print Publication: 2024).
DOI:	10.1183/23120541.00673-2023
Abstrakt:	Introduction: The clinical validity of real-world walking cadence in people with COPD is unsettled. Our objective was to assess the levels, variability and association with clinically relevant COPD characteristics and outcomes of real-world walking cadence. Methods: We assessed walking cadence (steps per minute during walking bouts longer than 10 s) from 7 days' accelerometer data in 593 individuals with COPD from five European countries, and clinical and functional characteristics from validated questionnaires and standardised tests. Severe exacerbations during a 12-month follow-up were recorded from patient reports and medical registries. Results: Participants were mostly male (80%) and had mean±sd age of 68±8 years, post-bronchodilator forced expiratory volume in 1 s (FEV 1 ) of 57±19% predicted and walked 6880±3926 steps·day -1 . Mean walking cadence was 88±9 steps·min -1 , followed a normal distribution and was highly stable within-person (intraclass correlation coefficient 0.92, 95% CI 0.90-0.93). After adjusting for age, sex, height and number of walking bouts in fractional polynomial or linear regressions, walking cadence was positively associated with FEV 1, 6-min walk distance, physical activity (steps·day -1 , time in moderate-to-vigorous physical activity, vector magnitude units, walking time, intensity during locomotion), physical activity experience and health-related quality of life and negatively associated with breathlessness and depression (all p<0.05). These associations remained after further adjustment for daily steps. In negative binomial regression adjusted for multiple confounders, walking cadence related to lower number of severe exacerbations during follow-up (incidence rate ratio 0.94 per step·min -1 , 95% CI 0.91-0.99, p=0.009). Conclusions: Higher real-world walking cadence is associated with better COPD status and lower severe exacerbations risk, which makes it attractive as a future prognostic marker and clinical outcome. Competing Interests: Conflict of interest: N. Karlsson reports owning stock in AstraZeneca, of which they are an employee; discourse made outside the submitted work. Conflict of interest: L. Palmerini reports being the co-founder of mHealth Technologies srl and owns shares of mHealth Technologies srl; disclosures made outside the submitted work. Conflict of interest: M.I. Polkey reports receiving consulting fees from Philips Respironics, outside the submitted work. Conflict of interest: D.A. Rodríguez Chiaradia reports grants or contracts from Janssen and Ferrer; consulting fees from Ferrer; payments for lectures, presentations, speakers bureaus, manuscript writing or educational events from Ferrer and Janssen; support for attending meetings and/or travel from Ferrer, MSD and Janssen; and participation on a Data Safety Monitoring Board or Advisory Board for Janssen, all outside the submitted work. Conflict of interest: R. Rodriguez-Roisin reports grants or contracts from Chiesi and Beyond Air NO, outside the submitted work. Conflict of interest: I. Vogiatzis is an associate editor of this journal. Conflict of interest: T. Troosters reports grants or contracts from Mobilise-D IHI funding, outside the submitted work. Conflict of interest: The remaining authors have nothing to disclose. (Copyright ©The authors 2024.)
Databáze:	MEDLINE
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