Full-field strain distribution in hierarchical electrospun nanofibrous poly-L(lactic) acid/collagen scaffolds for tendon and ligament regeneration: A multiscale study.

Autor: Sensini A; Department of Complex Tissue Regeneration and cell Biology-Inspired Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, the Netherlands.; Department of Industrial Engineering, Alma Mater Studiorum-Università di Bologna, Bologna, Italy., Stamati O; ESRF The European Synchrotron, Grenoble, France., Marchiori G; Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Sancisi N; Department of Industrial Engineering, Alma Mater Studiorum-Università di Bologna, Bologna, Italy., Gotti C; Advanced Mechanics and Materials - Interdepartmental Center for Industrial Research (CIRI-MAM), Alma Mater Studiorum-University of Bologna, Bologna, Italy., Giavaresi G; Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy., Cristofolini L; Department of Complex Tissue Regeneration and cell Biology-Inspired Tissue Regeneration, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, the Netherlands.; Health Sciences and Technologies-Interdepartmental Center for Industrial Research (HST-ICIR), Alma Mater Studiorum-Università di Bologna, I-40064, Ozzano dell'Emilia, Bologna, Italy., Focarete ML; Health Sciences and Technologies-Interdepartmental Center for Industrial Research (HST-ICIR), Alma Mater Studiorum-Università di Bologna, I-40064, Ozzano dell'Emilia, Bologna, Italy.; Department of Chemistry 'G. Ciamician' and National Consortium of Materials Science and Technology (INSTM, Bologna RU), Alma Mater Studiorum-Università di Bologna, Bologna, Italy., Zucchelli A; Department of Industrial Engineering, Alma Mater Studiorum-Università di Bologna, Bologna, Italy.; Advanced Mechanics and Materials - Interdepartmental Center for Industrial Research (CIRI-MAM), Alma Mater Studiorum-University of Bologna, Bologna, Italy., Tozzi G; Centre for Advanced Manufacturing and Materials, School of Engineering, University of Greenwich, Chatham Maritime, United Kingdom.
Jazyk: angličtina
Zdroj: Heliyon [Heliyon] 2024 Feb 24; Vol. 10 (5), pp. e26796. Date of Electronic Publication: 2024 Feb 24 (Print Publication: 2024).
DOI: 10.1016/j.heliyon.2024.e26796
Abstrakt: Regeneration of injured tendons and ligaments (T/L) is a worldwide need. In this study electrospun hierarchical scaffolds made of a poly-L (lactic) acid/collagen blend were developed reproducing all the multiscale levels of aggregation of these tissues. Scanning electron microscopy, microCT and tensile mechanical tests were carried out, including a multiscale digital volume correlation analysis to measure the full-field strain distribution of electrospun structures. The principal strains (ε p1 and ε p3 ) described the pattern of strains caused by the nanofibers rearrangement, while the deviatoric strains (ε D ) revealed the related internal sliding of nanofibers and bundles. The results of this study confirmed the biomimicry of such electrospun hierarchical scaffolds, paving the way to further tissue engineering and clinical applications.
Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Alberto Sensini has patent HIERARCHICAL MULTISCALE ELECTROSPUN SCAFFOLD FOR THE REGENERATION AND/OR REPLACEMENT OF THE TENDINOUS/LIGAMENTOUS TISSUE AND A METHOD FOR ITS PRODUCTION issued to Alma Mater Studiorum - Università di Bologna. Andrea Zucchelli has patent HIERARCHICAL MULTISCALE ELECTROSPUN SCAFFOLD FOR THE REGENERATION AND/OR REPLACEMENT OF THE TENDINOUS/LIGAMENTOUS TISSUE AND A METHOD FOR ITS PRODUCTION issued to Alma Mater Studiorum - Università di Bologna. Luca Cristofolini has patent HIERARCHICAL MULTISCALE ELECTROSPUN SCAFFOLD FOR THE REGENERATION AND/OR REPLACEMENT OF THE TENDINOUS/LIGAMENTOUS TISSUE AND A METHOD FOR ITS PRODUCTION issued to Alma Mater Studiorum - Università di Bologna. Maria Letizia Focarete has patent HIERARCHICAL MULTISCALE ELECTROSPUN SCAFFOLD FOR THE REGENERATION AND/OR REPLACEMENT OF THE TENDINOUS/LIGAMENTOUS TISSUE AND A METHOD FOR ITS PRODUCTION issued to Alma Mater Studiorum - Università di Bologna. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(© 2024 The Authors.)
Databáze: MEDLINE
Externí odkaz: