Skin erythematous migrant lesions consistent with histologically confirmed dermal arteriolar thrombosis connected to APS.

Autor: Suardi S; Department of Medicine, Unit of Internal Medicine, University of Verona, Verona, Italy., Croce J; Department of Medicine, Unit of Internal Medicine, University of Verona, Verona, Italy., Colato C; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Rizzo PC; Department of Diagnostics and Public Health, Section of Pathology, University of Verona, Verona, Italy., Friso S; Department of Medicine, Unit of Internal Medicine, University of Verona, Verona, Italy., Pizzolo F; Department of Medicine, Unit of Internal Medicine, University of Verona, Verona, Italy.
Jazyk: angličtina
Zdroj: Lupus [Lupus] 2024 Apr; Vol. 33 (5), pp. 532-535. Date of Electronic Publication: 2024 Mar 05.
DOI: 10.1177/09612033241238270
Abstrakt: Antiphospholipid syndrome (APS) is an acquired thrombophilic disorder related to the presence of antiphospholipid antibodies (LAC, anticardiolipin, anti Beta2-glycoprotein) known to cause venous and arterial thrombosis and recurrent pregnancy loss. Skin disorder is a frequent finding usually due to vascular thrombosis involving the dermal layer and can be either localized or widespread causing necrosis and ulceration of the skin, without histological evidence of vasculitis. We present a case of a woman with APS with both arterial and venous thrombotic involvement associated with an atypical dermatological manifestation histologically consistent with a pauci-inflammatory intermediate-deep dermal arteriolar platelet-mediated thrombosis that appeared despite anticoagulation with warfarin and responding to the addition of antiplatelet therapy.
Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze: MEDLINE
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