A Novel Anti-nucleocapsid Antibody Avidity Method for Identifying SARS-CoV-2 Reinfections.

Autor:	Golding L; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Watts AW; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada., Shew J; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Viñeta Paramo M; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Women+ and Children's Health, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada., Mâsse LC; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.; School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada., Goldfarb DM; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Abu-Raya B; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Lavoie PM; British Columbia Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.; Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; Women+ and Children's Health, Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2024 Sep 23; Vol. 230 (3), pp. e579-e583.
DOI:	10.1093/infdis/jiae072
Abstrakt:	Detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfections is challenging with current serology assays and is further complicated by the marked decrease in routine viral testing practices as viral transmission increased during Omicron. Here, we provide proof-of-principle that high-avidity anti-nucleocapsid (N) antibodies detects reinfections after a single infection with higher specificity (85%; 95% confidence interval [95% CI], 80%-90%) compared to anti-N antibody levels (72%; 95% CI, 66%-79%) in a vaccinated cohort. This method could be used to retroactively investigate the epidemiology and incremental long-term health consequences of SARS-CoV-2 reinfections. Competing Interests: Potential conflicts of interest . B. A. R. has received honoraria for participation in live meetings from Sanofi Pasteur France and Canada related to pertussis and RSV, but not for this work. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.)
Databáze:	MEDLINE
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