Phylogenomic and phenotypic analyses highlight the diversity of antibiotic resistance and virulence in both human and non-human Acinetobacter baumannii .
Autor: | Sykes EME; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Mateo-Estrada V; Programa de Genómica Evolutiva, Centro de Ciencias Génomicas, Universidad Nacional Autónoma de México, Cuernavaca, Mexico., Engelberg R; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Muzaleva A; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada., Zhanel G; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada., Dettman J; Ottawa Research and Development Centre (ORDC), Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada., Chapados J; Ottawa Research and Development Centre (ORDC), Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada., Gerdis S; Ottawa Research and Development Centre (ORDC), Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada., Akineden Ö; Dairy Sciences, Institute of Veterinary Food Science, Justus-Liebig, University of Giessen, Giessen, Germany., Khan IUH; Ottawa Research and Development Centre (ORDC), Agriculture and Agri-Food Canada, Ottawa, Ontario, Canada., Castillo-Ramírez S; Programa de Genómica Evolutiva, Centro de Ciencias Génomicas, Universidad Nacional Autónoma de México, Cuernavaca, Mexico., Kumar A; Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada. |
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Jazyk: | angličtina |
Zdroj: | MSphere [mSphere] 2024 Mar 26; Vol. 9 (3), pp. e0074123. Date of Electronic Publication: 2024 Mar 05. |
DOI: | 10.1128/msphere.00741-23 |
Abstrakt: | Acinetobacter baumannii is a Gram-negative, opportunistic pathogen that causes infections in the immunocompromised. With a high incidence of muti-drug resistance, carbapenem-resistant A. baumannii is designated as a priority 1 pathogen by the WHO. The current literature has expertly characterized clinical isolates of A. baumannii . As the challenge of these infections has recently been classified as a One Health issue, we set out to explore the diversity of isolates from human and non-clinical sources, such as agricultural surface water, urban streams, various effluents from wastewater treatment plants, and food (tank milk); and, importantly, these isolates came from a wide geographic distribution. Phylogenomic analysis considering almost 200 isolates showed that our diverse set is well-differentiated from the main international clones of A. baumannii . We discovered novel sequence types in both hospital and non-clinical settings and five strains that overexpress the resistance-nodulation-division efflux pump adeIJK without changes in susceptibility reflected by this overexpression. Furthermore, we detected a bla Competing Interests: The authors declare no conflict of interest. |
Databáze: | MEDLINE |
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