Investigation of directional discrimination in the nociceptive system using temperature-controlled laser stimuli.

Autor: Rujoie A; Integrative Neuroscience Group, Center for Neuroplasticity and Pain (CNAP), Department of Health Science & Technology, Aalborg University, Aalborg, Denmark., Andersen OK; Integrative Neuroscience Group, Center for Neuroplasticity and Pain (CNAP), Department of Health Science & Technology, Aalborg University, Aalborg, Denmark., Frahm KS; Integrative Neuroscience Group, Center for Neuroplasticity and Pain (CNAP), Department of Health Science & Technology, Aalborg University, Aalborg, Denmark.
Jazyk: angličtina
Zdroj: European journal of pain (London, England) [Eur J Pain] 2024 Sep; Vol. 28 (8), pp. 1320-1329. Date of Electronic Publication: 2024 Mar 05.
DOI: 10.1002/ejp.2259
Abstrakt: Background: Cutaneous laser stimulation has commonly been employed to investigate the thermal properties of the nociceptive system. The aim of this study was to investigate how a temperature-controlled laser system improves the assessment of directional discrimination in the nociceptive system.
Methods: In total, twenty healthy volunteers participated in this study. To determine the directional discrimination threshold (stimulation length 50% correct, expressed in mm), thermal stimuli were delivered using a diode laser and the laser beam was perpendicularly displaced across the skin to give a linear stimulation in four different directions (distal, proximal, lateral and medial) and displacement lengths (3 for lateral-medial and 5 for distal-proximal). Two temperature control modes were used in the stimulation system, open-loop and closed-loop control. The subjects had to report the perceived stimulus direction, the degree of certainty regarding the perceived direction and the intensity of the perceived stimulus (0-10 numerical rating scale, 3: pain threshold).
Results: During closed-loop control, the orientation of stimuli was discriminated significantly more accurately than during open-loop control. During closed-loop control, the directional discrimination threshold was 31.9 and 26.1 mm for distal-proximal and lateral-medial directed stimuli, respectively. A numerical rating scale was significantly higher for the lateral/medial directions. Moreover, the variability of the discrimination threshold is reduced in the closed-loop control system.
Conclusions: The findings show that discrimination ability is better in the lateral-medial directions compared to the distal-proximal directions. This study indicates that using a system enabling closed-loop temperature control, allows more robust probing of the temporo-spatial mechanisms in the nociceptive system.
Significance: This study shows that a newly developed temperature-controlled laser stimulation system enhances the possibilities to investigate the nociceptive temporo-spatial integration, as shown by a less variable directional discrimination threshold. The results also show that different orthogonal directions are discriminated differently. This new method allows a better investigation of the combined temporal and spatial mechanisms in the nociceptive system.
(© 2024 The Authors. European Journal of Pain published by John Wiley & Sons Ltd on behalf of European Pain Federation ‐ EFIC ®.)
Databáze: MEDLINE
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