Association between of vitamin B12 status during pregnancy and probable postpartum depression: the ECLIPSES study.

Autor: Cruz-Rodríguez J; Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira i Virgili (URV), Tarragona, Spain.; Nutrition and Mental Health Research Group (NUTRISAM), Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, Spain., Canals-Sans J; Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira i Virgili (URV), Tarragona, Spain.; Nutrition and Mental Health Research Group (NUTRISAM), Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, Spain.; Centre de Recerca en Avaluació i Mesura de la Conducta (CRAMC), Department of Psychology, Universitat Rovira i Virgili, Tarragona, Spain., Hernández-Martínez C; Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira i Virgili (URV), Tarragona, Spain.; Nutrition and Mental Health Research Group (NUTRISAM), Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, Spain.; Centre de Recerca en Avaluació i Mesura de la Conducta (CRAMC), Department of Psychology, Universitat Rovira i Virgili, Tarragona, Spain., Arija V; Nutrition and Mental Health Research Group (NUTRISAM), Universitat Rovira i Virgili (URV), Tarragona, Spain.; Nutrition and Mental Health Research Group (NUTRISAM), Institut d'Investigació Sanitària Pere Virgili (IISPV), Tarragona, Spain.; Centre de Recerca en Avaluació i Mesura de la Conducta (CRAMC), Department of Psychology, Universitat Rovira i Virgili, Tarragona, Spain.; Institut d'Investigació en Atenció Primària IDIAP Jordi Gol, Institut Català de la Salut (ICS), Barcelona, Spain.; Collaborative Research Group on Lifestyles, Nutrition and Smoking (CENIT), IDIAP Jordi Gol, Reus, Spain.
Jazyk: angličtina
Zdroj: Journal of reproductive and infant psychology [J Reprod Infant Psychol] 2024 Mar 05, pp. 1-15. Date of Electronic Publication: 2024 Mar 05.
DOI: 10.1080/02646838.2024.2324043
Abstrakt: Background: B12 vitamin is essential for the functioning of the nervous system and the production of mood-related neurotransmitters. However, information on its association with postpartum depression (PPD) is limited.
Objective: To examine the effect of serum vitamin B12 levels during pregnancy on PPD, in healthy pregnant women from the Mediterranean region of Catalonia, Spain.
Method: This longitudinal study included a subsample of women at 54 days (7.7 weeks) postpartum ( n  = 336), who participated in the ECLIPSES Study conducted out in Tarragona, Spain. Maternal concentrations of vitamin B12 were determined in the first and third trimester of pregnancy and sociodemographic, nutritional, and psychological data were collected. PPD was assessed using the Edinburgh Postnatal Depression Scale (EPDS).
Results: The prevalence of probable PPD was 21%. After adjusting for sociodemographic, lifestyle, biochemical parameters, and postpartum characteristics the regression model showed a negative association between EPDS scores and the highest quartile of serum vitamin B12 (first quartile (reference) vs. fourth quartile), (β = -1.267, 95% CI = -2.461, -0.073, p  = 0.038).
Conclusion: Maintaining a normal-high level of vitamin B12 during early pregnancy can contributes to preventing PPD.
Databáze: MEDLINE
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