Bioelectronic Medicine: a multidisciplinary roadmap from biophysics to precision therapies.

Autor:	González-González MA; Jan and Dan Duncan Neurological Research Institute, Texas Children's Hospital, Houston, TX, United States.; Department of Pediatric Neurology, Baylor College of Medicine, Houston, TX, United States., Conde SV; iNOVA4Health, NOVA Medical School, Faculdade de Ciências Médicas, NOVA University, Lisbon, Portugal., Latorre R; Centro Interdisciplinario de Neurociencia de Valparaíso, Facultad de Ciencias, Universidad de Valparaíso, Valparaíso, Chile., Thébault SC; Laboratorio de Investigación Traslacional en salud visual (D-13), Instituto de Neurobiología, Universidad Nacional Autónoma de México (UNAM), Querétaro, Mexico., Pratelli M; Neurobiology Department, Kavli Institute for Brain and Mind, UC San Diego, La Jolla, CA, United States., Spitzer NC; Neurobiology Department, Kavli Institute for Brain and Mind, UC San Diego, La Jolla, CA, United States., Verkhratsky A; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.; Achucarro Centre for Neuroscience, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.; Department of Forensic Analytical Toxicology, School of Forensic Medicine, China Medical University, Shenyang, China.; International Collaborative Center on Big Science Plan for Purinergic Signaling, Chengdu University of Traditional Chinese Medicine, Chengdu, China.; Department of Stem Cell Biology, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania., Tremblay MÈ; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.; Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada.; Department of Molecular Medicine, Université Laval, Québec City, QC, Canada.; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, BC, Canada., Akcora CG; Department of Computer Science, University of Central Florida, Orlando, FL, United States., Hernández-Reynoso AG; Department of Bioengineering, The University of Texas at Dallas, Richardson, TX, United States., Ecker M; Department of Biomedical Engineering, University of North Texas, Denton, TX, United States., Coates J; The Luxi Group, New Hartford, CT, United States., Vincent KL; Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, United States., Ma B; Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Houston, TX, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in integrative neuroscience [Front Integr Neurosci] 2024 Feb 19; Vol. 18, pp. 1321872. Date of Electronic Publication: 2024 Feb 19 (Print Publication: 2024).
DOI:	10.3389/fnint.2024.1321872
Abstrakt:	Bioelectronic Medicine stands as an emerging field that rapidly evolves and offers distinctive clinical benefits, alongside unique challenges. It consists of the modulation of the nervous system by precise delivery of electrical current for the treatment of clinical conditions, such as post-stroke movement recovery or drug-resistant disorders. The unquestionable clinical impact of Bioelectronic Medicine is underscored by the successful translation to humans in the last decades, and the long list of preclinical studies. Given the emergency of accelerating the progress in new neuromodulation treatments (i.e., drug-resistant hypertension, autoimmune and degenerative diseases), collaboration between multiple fields is imperative. This work intends to foster multidisciplinary work and bring together different fields to provide the fundamental basis underlying Bioelectronic Medicine. In this review we will go from the biophysics of the cell membrane, which we consider the inner core of neuromodulation, to patient care. We will discuss the recently discovered mechanism of neurotransmission switching and how it will impact neuromodulation design, and we will provide an update on neuronal and glial basis in health and disease. The advances in biomedical technology have facilitated the collection of large amounts of data, thereby introducing new challenges in data analysis. We will discuss the current approaches and challenges in high throughput data analysis, encompassing big data, networks, artificial intelligence, and internet of things. Emphasis will be placed on understanding the electrochemical properties of neural interfaces, along with the integration of biocompatible and reliable materials and compliance with biomedical regulations for translational applications. Preclinical validation is foundational to the translational process, and we will discuss the critical aspects of such animal studies. Finally, we will focus on the patient point-of-care and challenges in neuromodulation as the ultimate goal of bioelectronic medicine. This review is a call to scientists from different fields to work together with a common endeavor: accelerate the decoding and modulation of the nervous system in a new era of therapeutic possibilities. Competing Interests: JC is employee of RBI and founder of the Luxi Group. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. MAG-G was coordinator of the research topic collection “Women in neuroscience of Bioelectronic Medicine”, and SCT, MET and SVC were editors of the same research topic collection. This had no impact on the peer review process and the final decision. (Copyright © 2024 González-González, Conde, Latorre, Thébault, Pratelli, Spitzer, Verkhratsky, Tremblay, Akcora, Hernández-Reynoso, Ecker, Coates, Vincent and Ma.)
Databáze:	MEDLINE
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