Innovative snail-mucus-extract (SME)-coated nanoparticles exhibit anti-inflammatory and anti-proliferative effects for potential skin cancer prevention and treatment.

Autor:	Valeria C; Department of Drug and Health Sciences, University of Catania Via Santa Sofia 64 95125 Catania Italy sorrenti@unict.it.; CERNUT-Research Centre for Nutraceuticals and Health Products, University of Catania 95125 Catania Italy., Salvatore P; Department of Drug and Health Sciences, University of Catania Via Santa Sofia 64 95125 Catania Italy sorrenti@unict.it.; CNR-Institute of Biomolecular Chemistry Via Paolo Gaifami 18 95126 Catania Italy., Luca V; Department of Drug and Health Sciences, University of Catania Via Santa Sofia 64 95125 Catania Italy sorrenti@unict.it.; CERNUT-Research Centre for Nutraceuticals and Health Products, University of Catania 95125 Catania Italy., Maria G; Department of Drug and Health Sciences, University of Catania Via Santa Sofia 64 95125 Catania Italy sorrenti@unict.it., Ludovica M; Department of Drug and Health Sciences, University of Catania Via Santa Sofia 64 95125 Catania Italy sorrenti@unict.it., Cristina S; NanoHybrid Biointerfaces Laboratory (NHBIL), Department of Chemical Sciences, University of Catania Viale Andrea Doria, 6 95125 Catania Italy., Lucia M; Department of Drug and Health Sciences, University of Catania Via Santa Sofia 64 95125 Catania Italy sorrenti@unict.it.; CERNUT-Research Centre for Nutraceuticals and Health Products, University of Catania 95125 Catania Italy., Angela C; Mediterranean Nutraceutical Extracts (Medinutrex) Via Vincenzo Giuffrida 202 95128 Catania Italy., Valeria S; Department of Drug and Health Sciences, University of Catania Via Santa Sofia 64 95125 Catania Italy sorrenti@unict.it.; CERNUT-Research Centre for Nutraceuticals and Health Products, University of Catania 95125 Catania Italy.
Jazyk:	angličtina
Zdroj:	RSC advances [RSC Adv] 2024 Mar 04; Vol. 14 (11), pp. 7655-7663. Date of Electronic Publication: 2024 Mar 04 (Print Publication: 2024).
DOI:	10.1039/d4ra00291a
Abstrakt:	Nowadays, several studies have highlighted the ability of snail mucus in maintaining healthy skin conditions due to its emollient, regenerative and protective properties. In particular, mucus derived from H. aspersa muller has been reported to have beneficial effects such as antioxidant, antimicrobial activity and wound repair capacity. To enhance antioxidant activity of snail mucus, it was extracted in a hydroalcoholic solution and consequently freeze-dried. The obtained snail mucus extract (SME) was indeed endowed with higher antioxidant activity observed in cell-free models, however it was not possible to test its effects in cellular models as it creates a thick film on the cell surface. Therefore, in order to enhance beneficial effects of snail mucus and extend its potential use, SME was used to develop snail mucus extract-coated gold nanoparticles (AuNPs-SME) which exhibited anti-inflammatory properties on non-tumorigenic cells. LPS-induced inflammation in human NCTC keratinocytes was used as model to investigate the in vitro cytoprotective effects of nanoparticles. Co-treatment with LPS and AuNPs-SME significantly reduced pro-inflammatory cytokine transcription. Moreover, we demonstrated that AuNPs-SME not only can be used for anti-inflammatory treatments, but also as a sunscreen and antioxidant for potential cosmetic applications. Furthermore, AuNPs-SME's ability to selectively inhibit the growth of two human melanoma cell lines without affecting immortalized human keratinocyte viability in the same conditions was assessed. Thus, we demonstrated that snail mucus is suitable for creating innovative formulations and it can be considered a valid candidate for cosmeceutical applications to enrich the snail mucus based anti-age and sunscreen products already present on the market. Moreover, innovative formulations containing snail mucus can be potentially used for the treatment of specific skin neoplasms. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.)
Databáze:	MEDLINE
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