An Update on Protection of 5'-Hydroxyl Functions of Nucleosides and Oligonucleotides.

Autor: Seliger H; Polyverde GmbH, Antdorf, Germany., Sanghvi YS; Rasayan Inc., Encinitas, California.
Jazyk: angličtina
Zdroj: Current protocols [Curr Protoc] 2024 Mar; Vol. 4 (3), pp. e999.
DOI: 10.1002/cpz1.999
Abstrakt: The synthesis of natural and chemically modified nucleosides and oligonucleotides is in great demand due to its increasing number of applications in diverse areas of research. These include tools for diagnostics and proteomics, research reagents for molecular biology, probes for functional genomics, and the design, discovery, development, and manufacture of new therapeutics. The likelihood of success in synthesizing these molecules is often dependent on the correct choice of a protection strategy to block the 5'-hydroxyl group of a carbohydrate moiety, nucleoside, or oligonucleotide. This topic was reviewed extensively in the year 2000. The purpose of this article is to complement and update the original review with recently published methodologies recommended for the protection and deprotection of the 5'-hydroxyl group. © 2024 Wiley Periodicals LLC.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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