A register and questionnaire study of long-term general health symptoms following SARS-CoV-2 vaccination in Denmark.

Autor: O'Regan E; Department of Epidemiology Research, Statens Serum Institut, 2300, Copenhagen, Denmark. eior@ssi.dk., Svalgaard IB; Department of Epidemiology Research, Statens Serum Institut, 2300, Copenhagen, Denmark., Sørensen AIV; Infectious Disease Epidemiology and Prevention, Statens Serum Institut, 2300, Copenhagen, Denmark., Spiliopoulos L; Department of Epidemiology Research, Statens Serum Institut, 2300, Copenhagen, Denmark., Bager P; Department of Epidemiology Research, Statens Serum Institut, 2300, Copenhagen, Denmark.; Infectious Disease Epidemiology and Prevention, Statens Serum Institut, 2300, Copenhagen, Denmark., Nielsen NM; Department of Epidemiology Research, Statens Serum Institut, 2300, Copenhagen, Denmark.; Focused Research Unit in Neurology, Department of Neurology, Hospital of Southern Jutland, University of Southern Denmark, 6200, Aabenraa, Denmark., Hansen JV; Department of Epidemiology Research, Statens Serum Institut, 2300, Copenhagen, Denmark., Koch A; Infectious Disease Epidemiology and Prevention, Statens Serum Institut, 2300, Copenhagen, Denmark.; Department of Public Health, Global Health Section, University of Copenhagen, Copenhagen, Denmark.; Department of Infectious Diseases, Rigshospitalet University Hospital, 2100, Copenhagen, Denmark., Meder IK; Department of Epidemiology Research, Statens Serum Institut, 2300, Copenhagen, Denmark., Videbech P; Center for Neuropsychiatric Depression Research, Mental Health Center Glostrup, 2600 Glostrup, Denmark and University of Copenhagen, Copenhagen, Denmark., Ethelberg S; Infectious Disease Epidemiology and Prevention, Statens Serum Institut, 2300, Copenhagen, Denmark.; Department of Public Health, Global Health Section, University of Copenhagen, Copenhagen, Denmark., Hviid A; Department of Epidemiology Research, Statens Serum Institut, 2300, Copenhagen, Denmark.; Pharmacovigilance Research Centre, Department of Drug Design and Pharmacology, University of Copenhagen, 2100, Copenhagen, Denmark.
Jazyk: angličtina
Zdroj: NPJ vaccines [NPJ Vaccines] 2024 Mar 04; Vol. 9 (1), pp. 52. Date of Electronic Publication: 2024 Mar 04.
DOI: 10.1038/s41541-024-00844-w
Abstrakt: Many individuals who refuse COVID-19 vaccination have concerns about long-term side effects. Here, we report findings on self-reported symptoms from a Danish survey- and register study. The study included 34,868 vaccinated primary course recipients, 95.8% of whom received mRNA vaccines, and 1,568 unvaccinated individuals. Participants had no known history of SARS-CoV-2 infection. Using g-computation on logistic regression, risk differences (RDs) for symptoms between vaccinated and unvaccinated persons were estimated with adjustments for possible confounders. Within six weeks after vaccination, higher risks were observed for physical exhaustion (RD 4.9%, 95% CI 1.1% to 8.4%), fever or chills (RD 4.4%, 95% CI 2.1% to 6.7%), and muscle/joint pain (RD 7.0%, 95% CI 3.1% to 10.7%), compared to unvaccinated individuals. Beyond twenty-six weeks, risks were higher among the vaccinated for sleeping problems (RD 3.0, 95% 0.2 to 5.8), fever or chills (RD 2.0, 95% CI 0.4 to 3.6), reduced/altered taste (RD 1.2, 95% CI 0.2 to 2.3) and shortness of breath (RD 2.6, 95% CI 0.9 to 4.0). However, when examining pre-omicron responses only, the difference for reduced/altered taste was significant. As expected, the risk of experiencing physical exhaustion, fever or chills, and muscle/joint pain was higher among persons who responded within six weeks of completing the primary course. No significant differences were observed for the 7-25-week period after vaccination. Associations for the period beyond 26 weeks must be interpreted with caution and in the context of undetected SARS-CoV-2 infection, wide confidence intervals, and multiple testing. Overall, we observe no concerning signs of long-term self-reported physical, cognitive, or fatigue symptoms after vaccination.
(© 2024. The Author(s).)
Databáze: MEDLINE
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