Cavomycins A-C, Linear Oligomer Depsipeptides from an Annelid-Associated Streptomyces cavourensis .

Autor: Wang W; Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, Seoul 08826, Korea.; Research Institute of Oceanography, Seoul National University, Seoul 08826, Korea., Lee J; Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, Seoul 08826, Korea., Roh E; Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, NS-80, Seoul 08826, Korea., Shetye G, Cao J, McAlpine J, Pauli G, Franzblau S, Vu THN; Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam., Quach NT; Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam., Oh E; Research Institute of Oceanography, Seoul National University, Seoul 08826, Korea., Park KH; Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, Seoul 08826, Korea., Park C; Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, NS-80, Seoul 08826, Korea., Cho Y; Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, Seoul 08826, Korea., Jang H; Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, Seoul 08826, Korea., Han S; Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, Seoul 08826, Korea., Kim H; Department of Biomedical Science and Engineering, Konkuk University, Seoul 05029, Korea., Cho S, Phi QT; Institute of Biotechnology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi 100000, Vietnam., Kang H; Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, Seoul 08826, Korea.; Research Institute of Oceanography, Seoul National University, Seoul 08826, Korea.; Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, NS-80, Seoul 08826, Korea.
Jazyk: angličtina
Zdroj: Journal of natural products [J Nat Prod] 2024 Apr 26; Vol. 87 (4), pp. 976-983. Date of Electronic Publication: 2024 Mar 04.
DOI: 10.1021/acs.jnatprod.3c01275
Abstrakt: Three unique linear oligomeric depsipeptides, designated as cavomycins A-C ( 1 - 3 ), were identified from Streptomyces cavourensis , a gut bacterium associated with the annelid Paraleonnates uschakovi . The structures of these depsipeptides were determined through a combination of spectroscopic methods and chemical derivatization techniques, including methanolysis, the modified Mosher's method, advanced Marfey's methods, and phenylglycine methyl ester derivatization. The unique dipeptidyl residue arrangements in compounds 1 - 3 indicate that they are not degradation products of valinomycin. Compound 2 and its methylation derivative 2a exhibited antiproliferative activity against PANC-1 pancreatic cancer cells with IC 50 values of 1.2 and 1.7 μM, respectively.
Databáze: MEDLINE