Two previously undescribed cholestanol saponins from the rhizomes of Paris fargesii var. petiolata.

Autor: Tian YY; The College of Life Sciences, Northwest University, Xi'an 710069, China; Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an 710032, China., Bi LL; Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an 710032, China., Chen WW; Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an 710032, China., Zheng SX; School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang 712000, China., Cao Y; Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an 710032, China., Xie YH; The College of Life Sciences, Northwest University, Xi'an 710069, China., Tang HF; Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an 710032, China. Electronic address: tanghaifeng71@163.com., Lu YY; Department of Chinese Materia Medica and Natural Medicines, School of Pharmacy, Air Force Medical University, Xi'an 710032, China. Electronic address: luyunyanggq@163.com., Wang SW; The College of Life Sciences, Northwest University, Xi'an 710069, China. Electronic address: wangsiw@nwu.edu.cn.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2024 Jun; Vol. 175, pp. 105881. Date of Electronic Publication: 2024 Mar 02.
DOI: 10.1016/j.fitote.2024.105881
Abstrakt: Two previously undescribed cholestanol saponins, parpetiosides F - G (1-2), and six known analogs (3-8) were isolated from the rhizomes of Paris fargesii var. petiolata. Their structures were elucidated by extensive spectroscopic data analysis and chemical methods. Compound 1 was a rare 6/6/6/5/5 fused-rings cholestanol saponin with disaccharide moiety linked at C-26 of aglycone which was hardly seen in genus Paris. All of these compounds were discovered in this plant for the first time. In addition, the cytotoxicities of saponins (1-8) against three human cancer cell lines (U87, HepG2 and SGC-7901) were evaluated by CCK-8 method, and saponins 5-8 displayed certain cytotoxicities. The strong interactions between saponins 5-8 and SCUBE3, an oncogene for glioma cells, were displayed by molecular docking.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: