Relationship among sleep, work features, and SARS-cov-2 vaccine antibody response in hospital workers.

Autor: Tauman R; Sieratzki-Sagol Institute for Sleep Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. Electronic address: tauman@tlvmc.gov.il., Henig O; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Infectious Diseases and Infection Control, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Rosenberg E; School of Public Health. University of Haifa, Haifa, Israel., Marudi O; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Anesthesia, Pain Management and Intensive care, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Dunietz TM; Sieratzki-Sagol Institute for Sleep Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Grandner MA; Department of Psychiatry, Sleep and Health Research Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson, AZ, United States., Spitzer A; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Departments of Oncology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel., Zeltser D; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Emergency Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Mizrahi M; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Emergency Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Sprecher E; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Dermatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Department of Research and Development, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Ben-Ami R; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Infectious Diseases and Infection Control, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Goldshmidt H; Department of Clinical Laboratories, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Goldiner I; Department of Clinical Laboratories, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Saiag E; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Information Systems and Operations, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel., Angel Y; Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Department of Anesthesia, Pain Management and Intensive care, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Department of Physician Affairs, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Jazyk: angličtina
Zdroj: Sleep medicine [Sleep Med] 2024 Apr; Vol. 116, pp. 90-95. Date of Electronic Publication: 2024 Feb 29.
DOI: 10.1016/j.sleep.2024.02.045
Abstrakt: Study Objectives: Immunity is influenced by sleep and the circadian rhythm. Healthcare workers are predisposed to both insufficient sleep and circadian disruption. This study aimed to evaluate the relationship between sleep and work characteristics and the antibody response to the mRNA SARS-CoV-2 vaccine BNT162b2.
Methods: The authors' prospective cohort study ("COVI3") evaluated the effect of a third (booster) dose of the BNT162b2 vaccine. A subset of participants provided information on anthropometric measures, sleep, stress and work characteristics including shift work and number of work hours per week. Blood samples for anti-S1-RBD IgG antibody levels were obtained 21 weeks following receipt of the third dose of the vaccine.
Results: In total, 201 healthcare workers (73% women) were included. After adjustment for age, body mass index (BMI), shift work, smoking status, and perceived stress, short sleep duration (<7 h per night) was associated with lower anti-S1-RBD IgG levels (Odds ratio 2.36 [95% confidence interval 1.08-5.13]). Participants who performed shift work had higher odds of lower anti-S1-RBD IgG levels compared to those who did not work in shifts [odds ratio = 2.99 (95% confidence interval 1.40, 6.39)] after accounting for age, short sleep duration, BMI, smoking status and perceived stress.
Conclusions: Shift work and self-reported short sleep duration were associated with a lower antibody response following a booster dose of the SARS-CoV-2 vaccine. These findings suggest that the efficacy of vaccination, particularly among healthcare workers, may be augmented by addressing both sleep and circadian alignment.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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