The Evaluation of Effectiveness and Safety of Guselkumab in Patients with Psoriatic Arthritis in a Prospective Multicentre "Real-Life" Cohort Study.

Autor: Ruscitti P; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, P.O. box 67100, L'Aquila, Italy. piero.ruscitti@univaq.it., Cataldi G; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, P.O. box 67100, L'Aquila, Italy., Gentile M; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, P.O. box 67100, L'Aquila, Italy., Dionisi A; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, P.O. box 67100, L'Aquila, Italy., Volpe P; Rheumatology Unit, 'Santo Spirito' Hospital, Pescara, Italy., Finucci A; Rheumatology Unit, 'Santo Spirito' Hospital, Pescara, Italy., Verardi L; Rheumatology Unit, 'Santo Spirito' Hospital, Pescara, Italy., Di Muzio C; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, P.O. box 67100, L'Aquila, Italy., Italiano N; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, P.O. box 67100, L'Aquila, Italy., Celletti E; Department of Medicine and Science of Aging, Medical Clinic, SS. Annunziata Hospital of Chieti, 'G. D'Annunzio' University of Chieti-Pescara, Chieti, Italy., Di Penta M; Department of Medicine and Science of Aging, Medical Clinic, SS. Annunziata Hospital of Chieti, 'G. D'Annunzio' University of Chieti-Pescara, Chieti, Italy., Di Cola I; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, P.O. box 67100, L'Aquila, Italy., Marrelli A; Internal Medicine Unit, 'Giuseppe Mazzini' Hospital, Teramo, Italy., Alfonsi A; Internal Medicine Unit, 'Giuseppe Mazzini' Hospital, Teramo, Italy., Delle Monache F; Internal Medicine Unit, 'Giuseppe Mazzini' Hospital, Teramo, Italy., Cipollone F; Department of Medicine and Science of Aging, Medical Clinic, SS. Annunziata Hospital of Chieti, 'G. D'Annunzio' University of Chieti-Pescara, Chieti, Italy., Gabini M; Rheumatology Unit, 'Santo Spirito' Hospital, Pescara, Italy., Cipriani P; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, Delta 6 Building, P.O. box 67100, L'Aquila, Italy.
Jazyk: angličtina
Zdroj: Rheumatology and therapy [Rheumatol Ther] 2024 Jun; Vol. 11 (3), pp. 539-551. Date of Electronic Publication: 2024 Mar 04.
DOI: 10.1007/s40744-024-00649-2
Abstrakt: Introduction: Guselkumab is an interleukin-23 (IL-23) inhibitor licensed for the treatment of psoriatic arthritis (PsA). This study aimed to evaluate the 6-month effectiveness of guselkumab in patients with PsA in a "real-life" multicentre patient cohort. We also estimated the drug retention rate (DRR) of gusulkumab, also assessing the impact of comorbidities and patient clinical characteristics, in a collective 18-month prospective follow-up.
Methods: Between December 2021 and September 2023, consecutive patients with PsA were evaluated if treated at least for 6 months with guselkumab in a prospective multicentre study to evaluate the effectiveness of the drug by means of disease activity index for psoriatic arthritis (DAPSA) and cumulative DRR.
Results: A total of 111 patients with PsA were evaluated and treated with guselkumab (age 56.8 ± 9.9, male sex 20.7%). These patients were mainly characterised by active and long-standing PsA with median disease duration of 6.0 (7.0) years (55.9% disease duration ≥ 5 years), 55.0% showed comorbidities, 78.4% of patients were previously treated with biologic disease-modifying anti-rheumatic drugs (bDMARDs), and 60.4% concomitantly with conventional synthetic DMARDs (csDMARDs). After 6 months, a significant reduction of DAPSA was observed (β - 15.47, p = 0.001, 95% CI - 23.15 to - 9.79) with 39.6% of patients achieving a DAPSA ≤ 14. At the end of cumulative follow-up, 71.2% of patients were still treated with guselkumab whereas 24.3% discontinued the drug because of inefficacy. An 18-month DRR of guselkumab of 66.7% was estimated with a mean time of administration of 9.8 ± 4.1 months. The results of the DRR were stratified according to patient clinical characteristics. The DRR of guselkumab appeared to be not influenced by long disease duration, comorbidities, obesity, concomitant csDMARDs, and previous bDMARDs.
Conclusion: The "real-life" 6-month effectiveness of guselkumab was shown in patients with PsA, mainly characterised by active long-standing disease, previously treated with bDMARDs, and with comorbidities. Furthermore, a good DRR of guselkumab was estimated in the cumulative 18 months of follow-up and appeared to be not influenced by long disease duration, comorbidities, obesity, and previous bDMARDs.
(© 2024. The Author(s).)
Databáze: MEDLINE
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