Comparison of cerebral oxygen extraction fraction using ASE and TRUST methods in patients with sickle cell disease and healthy controls.

Autor:	Fellah S; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Ying C; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Wang Y; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Guilliams KP; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA., Fields ME; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA., Chen Y; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Lewis J; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Mirro A; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA., Cohen R; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Igwe N; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA., Eldeniz C; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Jiang D; Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Lu H; Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Powers WJ; Department of Neurology, Duke University School of Medicine, Durham, NC, USA., Lee JM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., Ford AL; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA., An H; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA.; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA.
Jazyk:	angličtina
Zdroj:	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism [J Cereb Blood Flow Metab] 2024 Aug; Vol. 44 (8), pp. 1404-1416. Date of Electronic Publication: 2024 Mar 04.
DOI:	10.1177/0271678X241237072
Abstrakt:	Abnormal oxygen extraction fraction (OEF), a putative biomarker of cerebral metabolic stress, may indicate compromised oxygen delivery and ischemic vulnerability in patients with sickle cell disease (SCD). Elevated OEF was observed at the tissue level across the brain using an asymmetric spin echo (ASE) MR method, while variable global OEFs were found from the superior sagittal sinus (SSS) using a T2-relaxation-under-spin-tagging (TRUST) MRI method with different calibration models. In this study, we aimed to compare the average ASE-OEF in the SSS drainage territory and TRUST-OEF in the SSS from the same SCD patients and healthy controls. 74 participants (SCD: N = 49; controls: N = 25) underwent brain MRI. TRUST-OEF was quantified using the Lu-bovine, Bush-HbA and Li-Bush-HbS models. ASE-OEF and TRUST-OEF were significantly associated in healthy controls after controlling for hematocrit using the Lu-bovine or the Bush-HbA model. However, no association was found between ASE-OEF and TRUST-OEF in patients with SCD using either the Bush-HbA or the Li-Bush-HbS model. Plausible explanations include a discordance between spatially volume-averaged oxygenation brain tissue and flow-weighted volume-averaged oxygenation in SSS or sub-optimal calibration in SCD. Further work is needed to refine and validate non-invasive MR OEF measurements in SCD. Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Databáze:	MEDLINE
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