Genomic epidemiology of antifungal resistance in human and avian isolates of Candida albicans : a pilot study from the One Health perspective.

Autor:	Domán M; HUN-REN Veterinary Medical Research Institute, Budapest, Hungary.; National Laboratory for Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, Budapest, Hungary., Kaszab E; HUN-REN Veterinary Medical Research Institute, Budapest, Hungary.; National Laboratory for Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, Budapest, Hungary.; One Health Institute, University of Debrecen, Debrecen, Hungary., Laczkó L; One Health Institute, University of Debrecen, Debrecen, Hungary.; HUN-REN-UD Conservation Biology Research Group, University of Debrecen, Debrecen, Hungary., Bali K; HUN-REN Veterinary Medical Research Institute, Budapest, Hungary.; National Laboratory for Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, Budapest, Hungary., Makrai L; Autovakcina Ltd., Budapest, Hungary., Kovács R; Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Majoros L; Department of Medical Microbiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary., Bányai K; HUN-REN Veterinary Medical Research Institute, Budapest, Hungary.; National Laboratory for Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, Budapest, Hungary.; Department of Pharmacology and Toxicology, University of Veterinary Medicine, Budapest, Hungary.
Jazyk:	angličtina
Zdroj:	Frontiers in veterinary science [Front Vet Sci] 2024 Feb 16; Vol. 11, pp. 1345877. Date of Electronic Publication: 2024 Feb 16 (Print Publication: 2024).
DOI:	10.3389/fvets.2024.1345877
Abstrakt:	Stress-induced genomic changes in Candida albicans contribute to the adaptation of this species to various environmental conditions. Variations of the genome composition of animal-origin C. albicans strains are largely unexplored and drug resistance or other selective pressures driving the evolution of these yeasts remained an intriguing question. Comparative genome analysis was carried out to uncover chromosomal aneuploidies and regions with loss of heterozygosity (LOH), two mechanisms that manage genome plasticity. We detected aneuploidy only in human isolates. Bird-derived isolates showed LOH in genes commonly associated with antifungal drug resistance similar to human isolates. Our study suggests that environmental fungicide usage might exert selective pressure on C. albicans infecting animals, thus contributing to the spread of potentially resistant strains between different hosts. Competing Interests: LMak was employed by Autovakcina Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Domán, Kaszab, Laczkó, Bali, Makrai, Kovács, Majoros and Bányai.)
Databáze:	MEDLINE
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