Systemic Chemotherapy for Advanced Hepatocellular Carcinoma in Patients With Child-Pugh class B.

Autor:	Kuwano A; Department of Hepatology, Aso Iizuka Hospital, Fukuoka, Japan., Yada M; Department of Hepatology, Aso Iizuka Hospital, Fukuoka, Japan., Tanaka K; Department of Hepatology, Aso Iizuka Hospital, Fukuoka, Japan., Koga Y; Department of Hepatology, Aso Iizuka Hospital, Fukuoka, Japan., Nagasawa S; Department of Hepatology, Aso Iizuka Hospital, Fukuoka, Japan., Masumoto A; Department of Hepatology, Aso Iizuka Hospital, Fukuoka, Japan., Motomura K; Department of Hepatology, Aso Iizuka Hospital, Fukuoka, Japan.
Jazyk:	angličtina
Zdroj:	Cancer diagnosis & prognosis [Cancer Diagn Progn] 2024 Mar 03; Vol. 4 (2), pp. 111-116. Date of Electronic Publication: 2024 Mar 03 (Print Publication: 2024).
DOI:	10.21873/cdp.10295
Abstrakt:	Background/aim: Numerous agents, including immune checkpoint inhibitors, are now available for hepatocellular carcinoma (HCC) treatment. Most trials involving systemic chemotherapy have included patients with Child-Pugh class A, while excluding or minimally enrolling those with Child-Pugh class B, due to liver dysfunction-related mortality. This study aimed to identify prognostic factors for survival in Child-Pugh class B patients receiving sorafenib (SOR), lenvatinib (LEN), atezolizumab plus bevacizumab (ATZ+BEV), or hepatic arterial infusion chemotherapy (HAIC). Patients and Methods: From December 2003 to June 2023, 137 patients with advanced HCC receiving systemic chemotherapies (SOR: n=43, LEN: n=16, ATZ+BEV: n=18, HAIC: n=60) were enrolled. Results: Overall survival (OS) and response rates did not differ significantly across treatments (SOR: 8.3 months, LEN: 10.2 months, ATZ+BEV: 8.5 months, HAIC: 7.3 months). Patients on HAIC and LEN had a lower rate of discontinuing treatment within three months compared to those on ATZ+BEV and SOR. HAIC was associated with fewer changes in ALBI score and better preservation of liver function. Multivariate logistic regression identified serum α-fetoprotein >400 ng/ml [hazard ratio (HR)=1.94; p=0.001], tumor count >5 (HR=1.55; p=0.043), and Child-Pugh score (HR=2.53; p=0.002) as independent predictors of OS. Conclusion: OS and response rates were similar across systemic chemotherapies. Prognosis for HCC in Child-Pugh class B patients was associated with liver function, necessitating further research for optimal treatment. Competing Interests: All Authors declare no competing interests in relation to this study. (Copyright 2024, International Institute of Anticancer Research.)
Databáze:	MEDLINE
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