Amelioration of oxygen-induced retinopathy in neonatal mice with fetal growth restriction.

Autor:	Watanabe R; Department of Pharmacology, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan.; Department of Pediatrics, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan., Liu S; Department of Pharmacology, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan., Sakaue T; Department of Cardiovascular and Thoracic Surgery, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan.; Department of Cell Growth and Tumor Regulation, Proteo-Science Center (PROS), Matsuyama, Ehime, Japan., Ikegawa Y; Department of Pharmacology, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan.; Department of Ophthalmology, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan., Ohta M; Department of Regional Pediatrics and Perinatology, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan., Higaki T; Department of Regional Child Health Care, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan., Mogi M; Department of Pharmacology, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan., Eguchi M; Department of Pediatrics, Ehime University Graduate School of Medicine, Matsuyama, Ehime, Japan.
Jazyk:	angličtina
Zdroj:	Frontiers in cell and developmental biology [Front Cell Dev Biol] 2024 Feb 16; Vol. 12, pp. 1288212. Date of Electronic Publication: 2024 Feb 16 (Print Publication: 2024).
DOI:	10.3389/fcell.2024.1288212
Abstrakt:	Introduction: With the aim of optimizing the balance of maintaining a safe oxygen saturation and reducing the risk of retinopathy of prematurity in human neonates with fetal growth restriction (FGR), the present study investigated the distinct effects of oxygen supplementation on the retinal neovasculature using a murine premature neonatal oxygen-induced retinopathy (OIR) model with or without fetal growth restriction. Methods: For comparison with normal birth-weight neonates, maternal low-protein diet-induced FGR neonates were subjected to fluctuating oxygen levels to generate oxygen-induced retinopathy. The retinal neovasculature was histologically evaluated, and comprehensive transcriptome analysis was conducted. Results: Compared to OIR neonates with normal birth weight, significant amelioration of the neovasculature, as indicated by decreases in the number of branch junctions, vascular distribution, maximal vascular radius and microaneurysm-like tufts, was observed in OIR mice with FGR. The results of retinal RNA-sequencing revealed downregulation of angiogenic factors that trigger pathological retinal neovascularization, such as the mitogen-activated protein kinase pathway and corresponding upstream signaling pathways in OIR mice with FGR. Conclusion : Our findings demonstrated that FGR neonates have a higher capacity for retinal oxygen stress, and the risk of OIR development is attenuated compared to that in mature neonates with normal birth weight. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Watanabe, Liu, Sakaue, Ikegawa, Ohta, Higaki, Mogi and Eguchi.)
Databáze:	MEDLINE
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