In vivo efficacy of 2% povidone iodine, chlorhexidine gluconate, and herbal extract mouthwash on SARS-CoV-2 viral load in saliva: A randomized clinical trial.
| Autor: | Nazrine S; Department of Periodontology, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India., Kulal R; Department of Periodontology, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India., Shivaprasad BM; Department of Periodontology, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India., Janardhanan N; Department of Periodontology, Rajarajeswari Dental College and Hospital, Bengaluru, Karnataka, India. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of Indian Society of Periodontology [J Indian Soc Periodontol] 2023 Nov-Dec; Vol. 27 (6), pp. 607-611. Date of Electronic Publication: 2024 Jan 24. |
| DOI: | 10.4103/jisp.jisp_469_22 |
| Abstrakt: | Background: One of the major techniques to reduce the transmission rate of COVID-19 would be to decrease the viral titers of SARS-CoV-2 in the saliva of infected patients and it is particularly useful in a dental setting. The present study evaluated the change in salivary viral load of COVID-19 patients using povidone iodine (PI), chlorhexidine (CHX), and an herbal extract (RightSure ® ) oral antiviral herbal mouthwash (HM) at clinically recommended duration and concentrations. Materials and Methods: Thirty individuals with SARS-CoV-2 were randomly allocated to three groups: (1) Group 1, PI mouthwash; (2) Group 2, CHX mouthwash; and (3) Group 3, HM mouthwash. A baseline salivary throat sample was collected from all the participants who were later instructed to rinse with their respective mouthwash for 30 s. A second salivary sample was collected 30 min after rinsing. The SARS-CoV-2 viral load was analyzed using real-time reverse-transcription polymerase chain reaction wherein the cyclic threshold (Ct) values were evaluated. Results: Independent t -test analysis reported a statistically significant difference concerning the PI group (before-after comparison) ( P < 0.05). The rest of the two study groups failed to report any significant difference in the nucleocapsid gene and open reading frame 1a gene levels. Conclusion: While all three types of mouthwash increased the Ct values, a statistically significant difference was observed with PI mouthwash, indicating that it might potentially reduce the spread of the SARS-CoV-2 virus, especially via aerosol but further studies with larger sample size and longer follow-up periods are required to investigate this relationship. Competing Interests: There are no conflicts of interest. (Copyright: © 2024 Indian Society of Periodontology.) |
| Databáze: | MEDLINE |
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