Evaluation of selected semen parameters and biomarkers of male infertility - preliminary study.

Autor:	Kups M; The Fertility Partnership Vitrolive in Szczecin, Szczecin, West Pomeranian Voivodeship, 70-483, Poland.; Department of Urology and Oncological Urology, Regional Specialist Hospital in Szczecin, Szczecin, West Pomeranian Voivodeship, 71-455, Poland., Gill K; Department of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Szczecin, West Pomeranian Voivodeship, 71-210, Poland., Rosiak-Gill A; The Fertility Partnership Vitrolive in Szczecin, Szczecin, West Pomeranian Voivodeship, 70-483, Poland.; Department of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Szczecin, West Pomeranian Voivodeship, 71-210, Poland., Harasny P; Department of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Szczecin, West Pomeranian Voivodeship, 71-210, Poland.; Department of Urology and Urological Oncology, Faculty of Medicine and Dentistry, Pomeranian Medical University in Szczecin, Szczecin, West Pomeranian Voivodeship, 70-111, Poland., Machalowski T; Department of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Szczecin, West Pomeranian Voivodeship, 71-210, Poland.; Department of Perinatology, Obstetrics and Gynecology, Faculty of Medicine and Dentistry, Pomeranian Medical University in Szczecin, Police, West Pomeranian Voivodeship, 72-010, Poland., Grabowska M; Department of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Szczecin, West Pomeranian Voivodeship, 71-210, Poland., Kurzawa R; The Fertility Partnership Vitrolive in Szczecin, Szczecin, West Pomeranian Voivodeship, 70-483, Poland.; Department of Gynecology and Reproductive Health, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Szczecin, West Pomeranian Voivodeship, 71-210, Poland., Sipak O; Department of Obstetrics and Pathology of Pregnancy, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Szczecin, Szczecin, West Pomeranian Voivodeship, 71-210, Poland., Piasecka M; Department of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University in Szczecin, Szczecin, West Pomeranian Voivodeship, 71-210, Poland.
Jazyk:	angličtina
Zdroj:	F1000Research [F1000Res] 2022 May 30; Vol. 11, pp. 591. Date of Electronic Publication: 2022 May 30 (Print Publication: 2022).
DOI:	10.12688/f1000research.121622.1
Abstrakt:	Background: Because the etiopathogenesis of male infertility is multifactorial our study was designed to clarify the relationship between standard semen parameters, testicular volume, levels of reproductive hormones and the fragmentation of sperm nuclear DNA (SDF). Methods: Patients (n = 130) were clustered as subjects: 1) with an abnormal volume (utrasonography) of at least one testis (<12 mL) or with a normal volume of testes and 2) with abnormal levels of at least one of the reproductive hormones (FSH, LH, PRL, TSH, total T - electrochemiluminescence method) or with normal hormonal profiles and 3) with high level of SDF (>30%), moderate (>15-30%) or low (≤15%) (sperm chromatin dispersion test). Results: In subjects with a decreased testicular volume and in subjects with abnormal levels of reproductive hormones, decreased basic semen parameters were found. Participants with abnormal testicular volume had a higher percentage of SDF and a higher level of FSH (Mann-Whitney U test). In turn, men with a high level of SDF had lower testicular volume and conventional sperm parameters than men with a low level of SDF (Kruskal-Wallis test). Conclusions : We showed that spermatogenesis disorders coexisted with decreased testicular volume and increased FSH levels. The disorders of spermatogenesis were manifested by reduced basic sperm characteristics and a high level of sperm nuclear DNA damage. Competing Interests: No competing interests were disclosed. (Copyright: © 2022 Kups M et al.)
Databáze:	MEDLINE
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