| Autor: |
Mamedova EO; Endocrinology Research Centre., Przhiyalkovskaya EG; Endocrinology Research Centre., Buryakina SA; Endocrinology Research Centre., Bondarenko EV; Endocrinology Research Centre., Lapshina AM; Endocrinology Research Centre., Pikunov MY; National medical research center for surgery named after A.V. Vishnevsky., Belaya ZE; Endocrinology Research Centre., Melnichenko GA; Endocrinology Research Centre. |
| Jazyk: |
ruština |
| Zdroj: |
Problemy endokrinologii [Probl Endokrinol (Mosk)] 2024 Feb 14; Vol. 70 (1), pp. 66-80. Date of Electronic Publication: 2024 Feb 14. |
| DOI: |
10.14341/probl13346 |
| Abstrakt: |
Acromegaly is a neuroendocrine disorder caused by excessive production of growth hormone (GH). In the majority of cases the cause of acromegaly is a pituitary tumor producing GH. Cases of ectopic acromegaly are much rarer. Ectopic acromegaly occurs in cases of tumors which produce growth hormone-releasing hormone (GHRH) or extrapituitary tumors which produce GH. The main sources of excessive GHRH production are neuroendocrine tumors (NETs) of the lung or pancreas. Treatment of ectopic acromegaly consists of surgical removal of the source of GHRH hyperproduction and in cases where surgery is not an option, somatostatin analogues, pegvisomant, chemotherapy, immunotherapy or radiation therapy are used.In this article three cases of ectopic acromegaly due to GHRH-producing lung NETs are presented, each of them being notable for a number of features. In the first two cases, clinical symptoms were mild, besides in the second case ectopic acromegaly was accompanied by primary hyperparathyroidism. In the third case ectopic acromegaly was accompanied by pituitary macroadenoma, and after surgical removal of the lung NET remission of acromegaly was not achieved. In all three cases, lung NETs were detected incidentally on radiologic chest screening for other conditions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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