The impact of primary headaches on disability outcomes: a literature review and meta-analysis to inform future iterations of the Global Burden of Disease study.

Autor: Waliszewska-Prosół M; Department of Neurology, Wroclaw Medical University, Wroclaw, Poland. marta.waliszewska@gmail.com., Montisano DA; Dipartimento Di Neuroalgologia, Centro Cefalee, Fondazione IRRCS Istituto Neurologico Carlo Besta, Milan, Italy. danilo.montisano@istituto-besta.it., Antolak M; Department of Neurology, Wroclaw Medical University, Wroclaw, Poland., Bighiani F; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, Pavia, Italy., Cammarota F; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, Pavia, Italy., Cetta I; Neuroimaging Research Unit and Neurology Unit, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Milan, Italy., Corrado M; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, Pavia, Italy., Ihara K; Department of Neurology, Keio University School of Medicine, Tokyo, Japan.; Japanese Red Cross, Ashikaga Hospital, Tochigi, Japan., Kartamysheva R; Department of Neurology, University Clinic of Kazan Federal University, Kazan, Russian Federation., Petrušić I; Faculty of Physical Chemistry, Laboratory for Advanced Analysis of Neuroimages, University of Belgrade, Belgrade, Serbia., Pocora MM; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, Pavia, Italy., Takizawa T; Department of Neurology, Keio University School of Medicine, Tokyo, Japan., Vaghi G; Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.; Headache Science & Neurorehabilitation Center, IRCCS Mondino Foundation, Pavia, Italy., Martelletti P; Unitelma Sapienza University of Rome, Rome, Italy., Corso B; Neuroscience Institute, National Research Council, Padua, Italy., Raggi A; SC Neurologia, Salute Pubblica, Disabilità, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Jazyk: angličtina
Zdroj: The journal of headache and pain [J Headache Pain] 2024 Mar 04; Vol. 25 (1), pp. 27. Date of Electronic Publication: 2024 Mar 04.
DOI: 10.1186/s10194-024-01735-0
Abstrakt: Background: The burden and disability associated with headaches are conceptualized and measured differently at patients' and populations' levels. At the patients' level, through patient-reported outcome measures (PROMs); at population level, through disability weights (DW) and years lived with a disability (YLDs) developed by the Global Burden of Disease Study (GBD). DW are 0-1 coefficients that address health loss and have been defined through lay descriptions. With this literature review, we aimed to provide a comprehensive analysis of disability in headache disorders, and to present a coefficient referring to patients' disability which might inform future GBD definitions of DW for headache disorders.
Methods: We searched SCOPUS and PubMed for papers published between 2015 and 2023 addressing disability in headache disorders. The selected manuscript included a reference to headache frequency and at least one PROM. A meta-analytic approach was carried out to address relevant differences for the most commonly used PROMs (by headache type, tertiles of medication intake, tertiles of females' percentage in the sample, and age). We developed a 0-1 coefficient based on the MIDAS, on the HIT-6, and on MIDAS + HIT-6 which was intended to promote future DW iterations by the GBD consortium.
Results: A total of 366 studies, 596 sub-samples, and more than 133,000 single patients were available, mostly referred to cases with migraine. Almost all PROMs showed the ability to differentiate disability severity across conditions and tertiles of medication intake. The indexes we developed can be used to inform future iterations of DW, in particular considering their ability to differentiate across age and tertiles of medication intake.
Conclusions: Our review provides reference values for the most commonly used PROMS and a data-driven coefficient whose main added value is its ability to differentiate across tertiles of age and medication intake which underlie on one side the increased burden due to aging (it is likely connected to the increased impact of common comorbidities), and by the other side the increased burden due to medication consumption, which can be considered as a proxy for headache severity. Both elements should be considered when describing disability of headache disorders at population levels.
(© 2024. The Author(s).)
Databáze: MEDLINE
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