Psoriasis dermatitis, a common phenotype of early forms of both psoriasis and atopic dermatitis in children: A prospective multicenter study.

Autor: Docampo-Simón A; Dermatology Department, Hospital General Universitario Dr Balmis, Alicante, Spain.; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain., Belinchón I; Dermatology Department, Hospital General Universitario Dr Balmis, Alicante, Spain.; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain.; Department of Clinical Medicine, Universidad Miguel Hernández, Elche, Spain., Sánchez-Pujol MJ; Dermatology Department, Hospital General Universitario Dr Balmis, Alicante, Spain.; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain., Berbegal L; Dermatology Department, Hospital de Dénia-Marina Salud, Denia, Spain., Miralles J; Dermatology Department, Hospital Universitario San Juan de Alicante, Sant Joan, Spain., Lucas A; Dermatology Department, Hospital General Universitario de Elda, Elda, Spain., Quecedo E; Dermatology Department, Hospital Arnau de Vilanova de Valencia, Valencia, Spain., Fuertes A; Dermatology Department, Hospital Universitario Dr Peset, Valencia, Spain., Mateu-Puchades A; Dermatology Department, Hospital Universitario Dr Peset, Valencia, Spain., Betlloch I; Dermatology Department, Hospital General Universitario Dr Balmis, Alicante, Spain.; Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Alicante, Spain.; Department of Clinical Medicine, Universidad Miguel Hernández, Elche, Spain.
Jazyk: angličtina
Zdroj: International journal of dermatology [Int J Dermatol] 2024 Oct; Vol. 63 (10), pp. 1392-1397. Date of Electronic Publication: 2024 Mar 03.
DOI: 10.1111/ijd.17100
Abstrakt: Background: Psoriasis (Ps) and atopic dermatitis (AD) are chronic systemic immune-mediated diseases that can coexist in an overlapping condition called psoriasis dermatitis (PD). PD patients have intermediate lesions with characteristics of both Ps and AD. PD is very rare in adults but much more frequent in children. Little is known, however, about the course of PD in the pediatric population. The aim of this study was to evaluate the percentage of PD cases in children that evolved to a definite form of Ps or AD and to identify any clinical or epidemiological variables that could predict the course of the disease.
Methods: We performed a prospective multicenter cohort study of children diagnosed with PD between January 2018 and December 2020. We collected participants' clinical and epidemiological characteristics, and pediatric dermatologists determined the percentage of participants who developed Ps or AD.
Results: The study included 24 children with PD, with a median age of 7.0 years. After a median follow-up period of 31 months, 83.3% of cases had evolved to a definite form of Ps or AD (44.4% to Ps and 38.9% to AD). Younger age and family history of Ps were associated with progression to AD. Participants who progressed to AD or Ps had a longer follow-up than those with an unchanged PD diagnosis.
Conclusions: Given sufficient time, a large percentage of PD cases in children will evolve into Ps or AD. Long-term clinical follow-up is necessary for a correct diagnosis.
(© 2024 The Authors. International Journal of Dermatology published by Wiley Periodicals LLC on behalf of the International Society of Dermatology.)
Databáze: MEDLINE
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