Amylovis-201 enhances physiological memory formation and rescues memory and hippocampal cell loss in a streptozotocin-induced Alzheimer's disease animal model.

Autor: Mercerón-Martínez D; Laboratorio de Electrofisiología Experimental del Centro Internacional de Restauración Neurológica, CIREN. Ave 25, # 15805, La Habana CP 11300, Cuba., Alacán Ricardo L; Facultad de Medicina Victoria de Girón, Universidad Médica de La Habana, Cuba., Bejerano Pina A; Facultad de Medicina Victoria de Girón, Universidad Médica de La Habana, Cuba., Orama Rojo N; Facultad de Biología, Universidad de La Habana, Cuba., Expósito Seco A; Facultad de Biología, Universidad de La Habana, Cuba., Vega Hurtado Y; Laboratorio de Electrofisiología Experimental del Centro Internacional de Restauración Neurológica, CIREN. Ave 25, # 15805, La Habana CP 11300, Cuba., Estupiñán Días B; Laboratorio de Histología del Centro Internacional de Restauración Neurología, CIREN. Ave 25, # 15805, La Habana CP 11300, Cuba., Fernández I; Laboratorio de Histología del Centro Internacional de Restauración Neurología, CIREN. Ave 25, # 15805, La Habana CP 11300, Cuba., García Pupo L; Centro de Neurociencias de Cuba, CNEURO. Ave 25, La Habana CP 11300, Cuba., Sablón Carrazana M; Centro de Neurociencias de Cuba, CNEURO. Ave 25, La Habana CP 11300, Cuba., Rodríguez-Tanty C; Centro de Neurociencias de Cuba, CNEURO. Ave 25, La Habana CP 11300, Cuba., Menéndez Soto Del Valle R; Centro de Neurociencias de Cuba, CNEURO. Ave 25, La Habana CP 11300, Cuba., Almaguer-Melian W; Laboratorio de Electrofisiología Experimental del Centro Internacional de Restauración Neurológica, CIREN. Ave 25, # 15805, La Habana CP 11300, Cuba. Electronic address: william@neuro.ciren.cu.
Jazyk: angličtina
Zdroj: Brain research [Brain Res] 2024 May 15; Vol. 1831, pp. 148848. Date of Electronic Publication: 2024 Mar 02.
DOI: 10.1016/j.brainres.2024.148848
Abstrakt: Alzheimer's disease is the most common neurodegenerative disease, and its treatment is lacking. In this work, we tested Amylovis-201, a naphthalene-derived compound, as a possible therapeutic candidate for the treatment of AD. For this purpose, we performed three experiments. In the first and third experiment, animals received a bilateral administration of streptozotocin and, starting 24 h after injection, a daily dose of Amylovis-201 (orally), for 17 days or for the whole time of the experiment respectively (28 days), after which learning and memory, as well as the number of hippocampal dentate gyrus cells, were assessed. In the second experiment, healthy animals received a single dose of Amylovis-201, 10 min or 5 h after the learning section to assess whether this substance could promote specific mechanisms involved in memory trace formation. Our data show that, administration of a single dose of Amylovis-201, 10 min after the end of training, but not at 5 h, produces a prolongation in memory duration, probably because it modulates specific mechanisms involved in memory trace consolidation. Furthermore, daily administration of Amylovis-201 to animals with bilateral intracerebroventricular injection of STZ produces a reduction in the loss of the hippocampus dentate gyrus cells and an improvement in spatial memory, probably because Amylovis-201 can interact with some of the protein kinases of the insulin signaling cascade, also involved in neural plasticity, and thereby halt or reverse some of the effects of STZ. Taking to account these results, Amylovis-201 is a good candidate for the therapeutic treatment of AD.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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