You can't handle the truth! Comparing serum phosphatidylethanol to self-reported alcohol intake in chronic liver disease patients.

Autor: Scholten K; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States. Electronic address: kscholten@unmc.edu., Twohig P; Department of Internal Medicine, Gastroenterology and Hepatology, University of Rochester Medical Center, Rochester, NY, United States., Samson K; Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States., Brittan K; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States., Fiedler A; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States., Warner J; Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States., Sempokuya T; Department of Medicine, The John A. Burns School of Medicine at the University of Hawaii at Manoa, Manoa, HI, United States., Willet A; Department of Internal Medicine, University of South Dakota School of Medicine, Sioux Falls, SD, United States., Peeraphatdit TB; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States., Olivera M; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Jazyk: angličtina
Zdroj: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2024 Jul; Vol. 56 (7), pp. 1215-1219. Date of Electronic Publication: 2024 Mar 01.
DOI: 10.1016/j.dld.2024.01.195
Abstrakt: Background: Serum phosphatidylethanol (PEth) testing has emerged as a promising biomarker for assessing recent alcohol consumption, surpassing the limitations of self-reported data. Limited clinical data exists comparing PEth levels and patients' reported alcohol intake.
Aims: Compare PEth testing results with self-reported alcohol intake and assesses variables associated with underreporting.
Methods: Single-center retrospective cohort of patients with a diagnosis of chronic liver disease and serum PEth. A patient's first positive PEth (>/=10 ng/mL) and self-reported alcohol consumption was used. PEth results were categorized as mild (10-20), moderate (20-200), or heavy (>200). Severity measures between self-report and PEth were assessed using Bhapkar's test and Bonferroni-adjusted McNemar's tests. Demographic data was analyzed using Chi-Square tests.
Results: 279 patients were included. 94 (33.7%) patients had consistency with self-report, and 185 patients had inconsistencies in their report (66.3%, p < 0.001). Of 279 patients, 161 (57.7%) underreported their alcohol consumption, and 55 (19.7%) heavy PEth patients underreported alcohol consumption as light. 58% of alcohol-related and 56.4% of non-alcohol-related cirrhotic patients underreported their alcohol use.
Conclusion: In our cohort, only one third of self-reported alcohol consumption was consistent with the PEth level. Notably, 57.7% underreported alcohol intake. Our study reinforces the clinical importance of PEth testing as an objective clinical measure.
Competing Interests: Conflict of interest All authors have no conflicts of interest or sources of financial support to disclose. Please reach out to the corresponding author for any questions or concerns.
(Copyright © 2024 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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