Clinical importance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and systemic immune-inflammation index in dogs with leishmaniasis.

Autor: Durán-Galea A; Hospital clínico Veterinario, Universidad de Extremadura, Avenida de la universidad s/n, Cáceres 10003, Spain., Cristóbal-Verdejo JI; Hospital clínico Veterinario, Universidad de Extremadura, Avenida de la universidad s/n, Cáceres 10003, Spain. Electronic address: jcristob@alumnos.unex.es., Barrera-Chacón R; Departamento de Medicina Animal, Universidad de Extremadura, Avenida de la Universidad s/n, Cáceres 10003, Spain., Macías-García B; Departamento de Medicina Animal, Universidad de Extremadura, Avenida de la Universidad s/n, Cáceres 10003, Spain., González-Solís MA; Departamento de Medicina Animal, Universidad de Extremadura, Avenida de la Universidad s/n, Cáceres 10003, Spain., Nicolás-Barceló P; Hospital clínico Veterinario, Universidad de Extremadura, Avenida de la universidad s/n, Cáceres 10003, Spain., García-Ibáñez AB; Hospital clínico Veterinario, Universidad de Extremadura, Avenida de la universidad s/n, Cáceres 10003, Spain., Ruíz-Tapia P; Departamento de Medicina Animal, Universidad de Extremadura, Avenida de la Universidad s/n, Cáceres 10003, Spain., Duque-Carrasco FJ; Departamento de Medicina Animal, Universidad de Extremadura, Avenida de la Universidad s/n, Cáceres 10003, Spain.
Jazyk: angličtina
Zdroj: Comparative immunology, microbiology and infectious diseases [Comp Immunol Microbiol Infect Dis] 2024 Apr; Vol. 107, pp. 102148. Date of Electronic Publication: 2024 Feb 23.
DOI: 10.1016/j.cimid.2024.102148
Abstrakt: Leishmaniasis is a zoonotic disease caused by Leishmania spp., impacts multiple systems and organs. While hematological and biochemical profiles aren't definitive for diagnosis, recent studies have identified the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and systemic immune-inflammation index (SII) as predictors of morbidity and mortality in critically ill human and dog patients. This study examined 100 dogs diagnosed with leishmaniasis, categorized by the International Renal Interest Society (IRIS) stages 1-4. Additionally, the dogs were divided based on whether they survived less or more than one year (L1Y and G1Y). Control group consisted of 43 dogs. The NLR increased as the disease progressed (IRIS 1-4), presenting statistically significant differences (P<0.05) when compared to the control group (2,37±2,08) IRIS 3 and 4 (4,59±13,39 and 6,99±12,86, respectively), and G1Y and L1Y (3,60±4,02 and 4,87±5,82, respectively). Significant changes in SII were only evident in short-term survivors (L1Y 951,93±1402) and advanced renal disease cases (IRIS 4 stage 1073,68±1901,09). Conversely, PLR remained largely unchanged. In conclusion, these results suggest that the neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII) may serve as potential markers for assessing disease progression and prognosis in dogs diagnosed with leishmaniasis.
Competing Interests: Declaration of Competing Interest The authors declare that they have no conflict of interest.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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