Nutritional strategies cause memory damage and alter biochemical parameters without causing neuroinflammation.

Autor: de Souza KR; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, 88704-900, Brazil., Engel NA; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, 88704-900, Brazil., Soares HJ; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, 88704-900, Brazil., Bressan CBC; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, 88704-900, Brazil., Dela Vedova LM; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, 88704-900, Brazil., da Silva LE; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, 88704-900, Brazil., Mendes TF; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, 88704-900, Brazil., da Silva MR; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, 88704-900, Brazil., de Oliveira MP; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, 88704-900, Brazil. 10722130172@ulife.com.br., Goulart AI; Laboratory of Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil., Córneo E; Laboratory of Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil., de Medeiros Borges H; Laboratory of Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil., Michels M; Laboratory of Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil., Bittencourt JVS; Laboratory of Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil., de Roch Casagrande L; Laboratory of Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil., Ferreira GK; SOCIESC Faculty of Education of São Bento do Sul, São Bento do Sul, Santa Catarina, Brazil., Petronilho FC; Laboratory of Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil., Dal-Pizzol F; Laboratory of Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil., Silveira PCL; Laboratory of Experimental Pathophysiology, Postgraduate Program in Health Sciences, University of the Extreme South of Santa Catarina, Criciúma, Santa Catarina, Brazil., de Bitencourt RM; Behavioral Neuroscience Laboratory, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., da Silva MG; Behavioral Neuroscience Laboratory, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Tubarão, Santa Catarina, Brazil., Rezin GT; Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Postgraduate Program in Health Sciences, University of Southern Santa Catarina, Av. José Acácio Moreira, 787, Tubarão, Santa Catarina, 88704-900, Brazil.
Jazyk: angličtina
Zdroj: Metabolic brain disease [Metab Brain Dis] 2024 Apr; Vol. 39 (4), pp. 635-648. Date of Electronic Publication: 2024 Mar 02.
DOI: 10.1007/s11011-023-01311-6
Abstrakt: Obesity results from an energy imbalance and has been considered an epidemic due to its increasing rates worldwide. It is classified as a low-grade chronic inflammatory disease and has associated comorbidities. Different nutritional strategies are used for the purpose of weight loss, highlighting low-carbohydrate (LC) diets, ketogenic diets, and intermittent fasting (IF). These strategies can lead to metabolic and behavioral changes as they stimulate different biochemical pathways. Therefore, this study evaluated memory, energy metabolism, neuroinflammation, oxidative stress, and antioxidant defense parameters in mice subjected to an LC diet, ketogenic diet (KD), or IF. Eighty male Swiss mice, 60 days old, were divided into 4 groups: control, LC, KD, or IF. Body weight was measured weekly, and food intake every 48 h. After 15 days of nutritional interventions, the animals were subjected to the behavioral object recognition test and subsequently euthanized. Then, visceral fat was removed and weighed, and the brain was isolated for inflammatory and biochemical analysis. We concluded from this study that the LC and KD strategies could damage memory, IF improves the production of adenosine triphosphate (ATP), and the LC, KD, and IF strategies do not lead to neuroinflammatory damage but present damage at the level of oxidative stress.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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