Lycopene possess an antimalarial effect on chloroquine-resistant malaria and its hematological aberrations in murine model.

Autor: Idih FM; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria Nsukka, Enugu State, Nigeria; Department of Biochemistry, Faculty of Natural Sciences, Prince Abubakar Audu University (formerly Kogi State University), Anyigba, Kogi State, Nigeria; Genomics and Molecular Biotechnology Research and Training Laboratory, Prince Abubakar Audu University (formerly Kogi State University), Anyigba, Kogi State, Nigeria. Electronic address: idih.fm@ksu.edu.ng., Atanu FO; Department of Biochemistry, Faculty of Natural Sciences, Prince Abubakar Audu University (formerly Kogi State University), Anyigba, Kogi State, Nigeria., Ndu CK; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria Nsukka, Enugu State, Nigeria; Nile University of Nigeria, Abuja, Nigeria., Michael RE; Department of Biochemistry, Faculty of Natural Sciences, Prince Abubakar Audu University (formerly Kogi State University), Anyigba, Kogi State, Nigeria; Genomics and Molecular Biotechnology Research and Training Laboratory, Prince Abubakar Audu University (formerly Kogi State University), Anyigba, Kogi State, Nigeria., Kadiri B; Department of Biochemistry, Faculty of Natural Sciences, Prince Abubakar Audu University (formerly Kogi State University), Anyigba, Kogi State, Nigeria; Genomics and Molecular Biotechnology Research and Training Laboratory, Prince Abubakar Audu University (formerly Kogi State University), Anyigba, Kogi State, Nigeria., Jimoh LO; Department of Biochemistry, Faculty of Natural Sciences, Prince Abubakar Audu University (formerly Kogi State University), Anyigba, Kogi State, Nigeria; Genomics and Molecular Biotechnology Research and Training Laboratory, Prince Abubakar Audu University (formerly Kogi State University), Anyigba, Kogi State, Nigeria., Usman BO; Department of Biochemistry, Faculty of Natural Sciences, Prince Abubakar Audu University (formerly Kogi State University), Anyigba, Kogi State, Nigeria; Genomics and Molecular Biotechnology Research and Training Laboratory, Prince Abubakar Audu University (formerly Kogi State University), Anyigba, Kogi State, Nigeria., Ogugua VN; Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria Nsukka, Enugu State, Nigeria.
Jazyk: angličtina
Zdroj: Parasitology international [Parasitol Int] 2024 Aug; Vol. 101, pp. 102873. Date of Electronic Publication: 2024 Feb 28.
DOI: 10.1016/j.parint.2024.102873
Abstrakt: Malaria remains a major public health issue worldwide, with high rates of morbidity and mortality. The resistance of Plasmodium parasites to commonly used antimalarial drugs has necessitated the development of novel drugs and targets for malaria treatment. Lycopene is a natural compound present in tomatoes and other red fruits and vegetables. This study aimed to evaluate the antimalarial activity of lycopene and its co-administration with chloroquine against chloroquine-resistant malaria, as well as to assess its impact on hematological abnormalities associated with malaria infection. The experimental animals for this study were infected with 10 7 NK65 Plasmodium berghei-infected red blood cells via intraperitoneal injection. The animals were then treated with artemether-lumefantrine, chloroquine, and varying doses of lycopene. The study evaluated percentage parasitemia, mean survival time, and various hematological parameters, including red blood cell count, hematocrit, hemoglobin concentration, mean corpuscular volume, mean corpuscular hemoglobin, red blood cell distribution width - coefficient of variation, red blood cell distribution width - standard deviation, white blood cell count, granulocyte count, lymphocyte count, monocyte count, and procalcitonin level. The study revealed that lycopene demonstrated significant (p < 0.05) antimalarial activity and the ability to ameliorate hematological abnormalities associated with acute malaria infection. The findings of this study highlight the potential of lycopene as a novel antimalarial agent. The results of this study may contribute to the development of new drugs for malaria treatment, particularly in low- and middle-income countries.
Competing Interests: Declaration of competing interest The Authors declare that there is no conflict of interest regarding the research, authorship and publication of this article.
(Copyright © 2023. Published by Elsevier B.V.)
Databáze: MEDLINE
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