Pulmonary function and trajectories of cognitive decline in aging population.
Autor: | Ksinan AJ; RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic. Electronic address: albert.ksinan@recetox.muni.cz., Dalecká A; RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic., Court T; RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic., Pikhart H; RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic; Department of Epidemiology & Public Health, University College London, Institute of Epidemiology and Health Care, London, UK., Bobák M; RECETOX, Faculty of Science, Masaryk University, Brno, Czech Republic; Department of Epidemiology & Public Health, University College London, Institute of Epidemiology and Health Care, London, UK. |
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Jazyk: | angličtina |
Zdroj: | Experimental gerontology [Exp Gerontol] 2024 May; Vol. 189, pp. 112386. Date of Electronic Publication: 2024 Mar 18. |
DOI: | 10.1016/j.exger.2024.112386 |
Abstrakt: | Background: The number of older people with cognitive impairment is increasing worldwide. Impaired lung function might be associated with cognitive decline in older age; however, results from large longitudinal studies are lacking. In this study, we examined the longitudinal associations between pulmonary function and the trajectories of cognitive decline using prospective population-based SHARE data from 14 countries. Methods: The analytic sample included N = 32,049 older adults (Mean age at baseline = 64.76 years). The dependent variable was cognitive performance, measured repeatedly across six waves in three domains: verbal fluency, memory, and numeracy. The main predictor of interest was peak expiratory flow (PEF). The data were analyzed in a multilevel accelerated longitudinal design, with models adjusted for a variety of covariates. Results: A lower PEF score was associated with lower cognitive performance for each domain as well as a lower global cognitive score. These associations remained statistically significant after adjusting for all covariates Q4 vs Q1 verbal fluency: unstandardized coefficient B = -3.15; numeracy: B = -0.52; memory: B = -0.64; global cognitive score B = -2.65, all p < .001). However, the PEF score was not found to be associated with the rate of decline for either of the cognitive outcomes. Conclusions: In this large multi-national longitudinal study, the PEF score was independently associated with lower levels of cognitive functions, but it did not predict a future decline. The results suggest that pre-existing differences in lung functions are responsible for variability in cognitive functions and that these differences remained stable across aging. Competing Interests: Declaration of competing interest None. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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