Mediator complex subunit 1 architects a tumorigenic Treg cell program independent of inflammation.
Autor: | Chaudhuri SM; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Weinberg SE; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Wang D; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Yalom LK; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Montauti E; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Iyer R; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Tang AY; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Torres Acosta MA; Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Medical Scientist Training Program, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Shen J; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Mani NL; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Wang S; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Liu K; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Lu W; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Bui TM; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Manzanares LD; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Dehghani Z; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Wai CM; Center for Genetic Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Gao B; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Wei J; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Yue F; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Cui W; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Singer BD; Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Sumagin R; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Zhang Y; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA., Fang D; Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: fangd@northwestern.edu. |
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Jazyk: | angličtina |
Zdroj: | Cell reports. Medicine [Cell Rep Med] 2024 Mar 19; Vol. 5 (3), pp. 101441. Date of Electronic Publication: 2024 Feb 29. |
DOI: | 10.1016/j.xcrm.2024.101441 |
Abstrakt: | While immunotherapy has revolutionized cancer treatment, its safety has been hampered by immunotherapy-related adverse events. Unexpectedly, we show that Mediator complex subunit 1 (MED1) is required for T regulatory (T Competing Interests: Declaration of interests B.D.S. holds United States Patent No. US 10,905,706 B2, “Compositions and Methods to Accelerate Resolution of Acute Lung Inflammation” and serves on the Scientific Advisory Board of Zoe Biosciences, outside of the submitted work. (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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