Chemical Constituents of Ajuga Lupulina and their Anti-Ferroptosis Activity.
| Autor: | Teng X; Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China., Shi H; Guangdong Provincial Engineering and Technology Research Center of Cosmetics, Guangdong Pharmaceutical University, Zhongshan, 528458, People's Republic of China.; Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China., Cao L; Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China., Peng X; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China., He L; Guangdong Provincial Engineering and Technology Research Center of Cosmetics, Guangdong Pharmaceutical University, Zhongshan, 528458, People's Republic of China.; Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Guangdong Pharmaceutical University, Guangzhou, 510006, People's Republic of China., Gu Q; Research Center for Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, People's Republic of China. |
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| Jazyk: | angličtina |
| Zdroj: | Chemistry & biodiversity [Chem Biodivers] 2024 Apr; Vol. 21 (4), pp. e202400244. Date of Electronic Publication: 2024 Mar 18. |
| DOI: | 10.1002/cbdv.202400244 |
| Abstrakt: | Five new compounds (1, 2, 7, 12, and 16), along with fifteen known ones, were isolated from Ajuga lupulina Maxim. Their structures were revealed by analysing spectroscopic data (MS, NMR), and experimental and calculated ECD spectra was used to deduce the absolute configuration. Compound 16, with eight carbon atoms, was firstly isolated from the nature. All the isolates were evaluated for their inhibitory effect on RSL3-induced ferroptosis in HT22 mouse hippocampal neuronal cells. Among them, the abietane-type diterpenoids (7-11) significantly inhibited ferroptosis with EC (© 2024 Wiley‐VHCA AG, Zurich, Switzerland.) |
| Databáze: | MEDLINE |
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