Factors associated with older adults' cognitive decline 6 months after gamma-variant SARS-CoV-2 infection.
| Autor: | Peixoto VGMNP; Post-graduation Program in Psychobiology, Universidade Federal do Rio Grande do Norte, Natal, Brazil.; Department of Clinical Medicine, Universidade Federal do Rio Grande do Norte, Natal, Brazil., Facci LA; Universidade Federal do Rio Grande do Norte, Natal, Brazil., Barbalho TCS; Universidade Federal do Rio Grande do Norte, Natal, Brazil., Souza RN; Universidade Federal do Rio Grande do Norte, Natal, Brazil., Duarte AM; Universidade Federal do Rio Grande do Norte, Natal, Brazil., Dos Santos MB; Department of Psychology, Universidade Federal do Rio Grande do Norte, Natal, Brazil., Almondes KM; Post-graduation Program in Psychobiology, Universidade Federal do Rio Grande do Norte, Natal, Brazil.; Department of Psychology, Universidade Federal do Rio Grande do Norte, Natal, Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in neurology [Front Neurol] 2024 Feb 15; Vol. 15, pp. 1334161. Date of Electronic Publication: 2024 Feb 15 (Print Publication: 2024). |
| DOI: | 10.3389/fneur.2024.1334161 |
| Abstrakt: | Background: Cognitive deficits are commonly reported after COVID-19 recovery, but little is known in the older population. This study aims to investigate possible cognitive damage in older adults 6 months after contracting COVID-19, as well as individual risk factors. Methods: This cross-sectional study involved 70 participants aged 60-78 with COVID-19 6 months prior and 153 healthy controls. Montreal Cognitive Assessment-Basic (MoCA-B) screened for cognitive impairment; Geriatric Depression Scale and Geriatric Anxiety Inventory screened for depression and anxiety. Data were collected on demographics and self-reports of comorbid conditions. Results: The mean age of participants was 66.97 ± 4.64 years. A higher proportion of individuals in the COVID group complained about cognitive deficits (χ 2 = 3.574; p = 0.029) and presented with deficient MoCA-B scores (χ 2 = 6.098, p = 0.014) compared to controls. After controlling for multiple variables, all the following factors resulted in greater odds of a deficient MoCA-B: COVID-19 6-months prior (OR, 2.44; p = 0.018), age (OR, 1.15; p < 0.001), lower income (OR, 0.36; p = 0.070), and overweight (OR, 2.83; p = 0.013). Further analysis pointed to individual characteristics in COVID-19-affected patients that could explain the severity of the cognitive decline: age ( p = 0.015), lower income ( p < 0.001), anxiety ( p = 0.049), ageusia ( p = 0.054), overweight ( p < 0.001), and absence of cognitively stimulating activities ( p = 0.062). Conclusion: Our study highlights a profile of cognitive risk aggravation over aging after COVID-19 infection, which is likely mitigated by wealth but worsened in the presence of overweight. Ageusia at the time of acute COVID-19, anxiety, being overweight, and absence of routine intellectual activities are risk factors for more prominent cognitive decline among those infected by COVID-19. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Peixoto, Facci, Barbalho, Souza, Duarte, dos Santos and Almondes.) |
| Databáze: | MEDLINE |
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