Randomized comparison between KTd and KRd induction therapy followed by maintenance therapy with K or observation in transplant-ineligible patients with newly diagnosed multiple myeloma.

Autor: Ludwig H; Department of Medicine I, Clinic Ottakring, Wilhelminen Cancer Research Institute, Vienna, Austria., Melchardt T; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Cancer Cluster Salzburg, Salzburg, Austria., Sormann S; Department of Hematology, University Clinic for Internal Medicine, Graz, Austria., Schreder M; Department of Medicine I, Clinic Ottakring, Vienna, Austria., Andel J; Department of Internal Medicine II, Pyhrn-Eisenwurzen Klinikum Steyr, Steyr, Austria., Hartmann B; Department of Internal Medicine II, LKH Rankweil, Rankweil, Austria., Tinchon C; Department for Hematology, Oncology and Palliative Care, LKH Hochsteiermark, Standort Leoben, Standort Leoben, Austria., Zojer N; Department of Medicine I, Clinic Ottakring, Vienna, Austria., Gunsilius E; Department of Internal Medicine V, Medical University Innsbruck, Innsbruck, Austria., Podar K; Department of Internal Medicine II, University Hospital Krems, Krems an der Donau, Austria.; Molecular Oncology and Hematology Unit, Karl Landsteiner University of Health Sciences, Krems an der Donau, Austria., Egle A; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Cancer Cluster Salzburg, Salzburg, Austria., Willenbacher W; Department of Internal Medicine V, Medical University Innsbruck, Innsbruck, Austria.; syndena GmbH, Connect to Cure, Innsbruck, Austria., Wöll E; Department of Internal Medicine, St. Vinzenz Krankenhaus Zams, Zams, Austria., Ruckser R; Department of Medicine II, Clinic Donaustadt, Vienna, Austria., Bozic B; Department of Medicine II, Clinic Donaustadt, Vienna, Austria., Krauth MT; University Clinic for Internal Medicine I, AKH, Medical University of Vienna, Vienna, Austria., Petzer A; Department of Internal Medicine I, BHS Linz, Linz, Austria., Schmitt C; Clinic for Internal Medicine 3, Kepler University Clinic Linz, Linz, Austria., Machherndl-Spandl S; Department of Internal Medicine I, Elisabethinen, Linz, Austria., Agis H; Department of Internal Medicine I, Division of Oncology, Medical University Vienna, Vienna, Austria., Fillitz M; Department of Internal Medicine, Hanusch Krankenhaus, Vienna, Austria., Wang SY; Medical Clinic and Policlinic I, University Clinic Leipzig, Leipzig, Germany., Zabernigg A; Department of Internal Medicine, Kufstein County Hospital, Kufstein, Austria., Knop S; Klinik für Innere Medizin 5, Schwerpunkt Onkologie/Hämatologie, Klinikum Nürnberg Nord, Nürnberg, Germany., Paiva B; Clínica Universidad de Navarra, Centro de Investigación Médica Aplicada (CIMA), CCUN, IDISNA, Pamplona, Spain., Greil R; Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Oncologic Center, Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Cancer Cluster Salzburg, Salzburg, Austria.
Jazyk: angličtina
Zdroj: American journal of hematology [Am J Hematol] 2024 May; Vol. 99 (5), pp. 1008-1011. Date of Electronic Publication: 2024 Feb 29.
DOI: 10.1002/ajh.27280
Abstrakt: Randomized comparison between KTd and KRd induction followed by second randomization to carfilzomib in transplant-ineligable patients with newly diagnosed multiple myeloma.
(© 2024 Wiley Periodicals LLC.)
Databáze: MEDLINE
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