Establishment of clinical criteria for the diagnosis of adverse food reactions in dogs with atopic dermatitis.

Autor: Sofou EI; Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Karditsa, Greece., Aleksandrova S; Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Karditsa, Greece., Chatzis M; Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Karditsa, Greece., Samuel Badulescu E; Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Karditsa, Greece., Saridomichelakis MN; Clinic of Medicine, Faculty of Veterinary Science, University of Thessaly, Karditsa, Greece.
Jazyk: angličtina
Zdroj: Veterinary dermatology [Vet Dermatol] 2024 Aug; Vol. 35 (4), pp. 418-431. Date of Electronic Publication: 2024 Feb 29.
DOI: 10.1111/vde.13247
Abstrakt: Background: Diagnosis of canine adverse food reactions (AFRs) is based on vague criteria, such as '>50% improvement' during elimination diet trial (EDT) followed by 'deterioration' during provocation test (PT).
Objective: The objective of the study was to use predefined criteria to evaluate response during EDT [i.e., Owner Global Assessment of Treatment Efficacy (OGATE) = good-to-excellent] and relapse during PT [i.e., Owner Global Assessment of Challenge Deterioration (OGACD) = moderate-to-severe and/or >100% increase of lesional (Canine Atopic Dermatitis Extent and Severity Index, 4th iteration, CADESI-04) and/or of pruritus (pruritus Visual Analog Scale, PVAS) scores].
Animals: Twenty-nine dogs with atopic dermatitis.
Materials and Methods: An extensively hydrolysed diet was fed to all dogs followed, in seven of 11 nonresponders, by a second home-made novel-protein EDT. Dogs responding to either EDT were challenged with their previous diet.
Results: Thirteen (44.8%) dogs were diagnosed with AFRs: at the end of EDT, their OGATE was good (9 of 13; 69.2%) or excellent (four of 13; 30.8%), and both CADESI-04 (46.7%) and PVAS (71.1%) had decreased significantly; at the end of PT, OGACD was moderate or severe in 12 of 13 (92.3%) dogs, and both CADESI-04 (127.9%) and PVAS (181.8%) had increased significantly. Of the 16 dogs without AFRs, 6 (37.5%) responded to the commercial (n = 5) or home-made (n = 1) diet [OGATE = good (three of six) or excellent (three of six)], with significant concurrent reduction of CADESI-04 and nonsignificant reduction of PVAS, yet they did not relapse during PT.
Conclusions and Clinical Relevance: The proposed (predefined) criteria for the evaluation of response during EDT and deterioration during PT seem reliable and are easily applicable in clinical practice and research.
(© 2024 The Authors. Veterinary Dermatology published by John Wiley & Sons Ltd on behalf of ESVD and ACVD.)
Databáze: MEDLINE
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