Peroxisome-based metabolic engineering for biomanufacturing and agriculture.

Autor: Song S; State Key Laboratory of Rice Biology and Breeding, College of Chemical and Biological Engineering, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311215, Zhejiang, China., Ye C; State Key Laboratory of Rice Biology and Breeding, College of Chemical and Biological Engineering, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311215, Zhejiang, China., Jin Y; State Key Laboratory of Rice Biology and Breeding, College of Chemical and Biological Engineering, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311215, Zhejiang, China., Dai H; Beijing Life Science Academy, Changping 102209, Beijing, China., Hu J; Michigan State University-Department of Energy Plant Research Laboratory and Plant Biology Department, Michigan State University, East Lansing, MI 48824, USA., Lian J; State Key Laboratory of Rice Biology and Breeding, College of Chemical and Biological Engineering, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311215, Zhejiang, China. Electronic address: jzlian@zju.edu.cn., Pan R; State Key Laboratory of Rice Biology and Breeding, College of Chemical and Biological Engineering, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou 310058, Zhejiang, China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Zhejiang University, Hangzhou 311215, Zhejiang, China. Electronic address: panr@zju.edu.cn.
Jazyk: angličtina
Zdroj: Trends in biotechnology [Trends Biotechnol] 2024 Sep; Vol. 42 (9), pp. 1161-1176. Date of Electronic Publication: 2024 Feb 28.
DOI: 10.1016/j.tibtech.2024.02.005
Abstrakt: Subcellular compartmentalization of metabolic pathways plays a crucial role in metabolic engineering. The peroxisome has emerged as a highly valuable and promising compartment for organelle engineering, particularly in the fields of biological manufacturing and agriculture. In this review, we summarize the remarkable achievements in peroxisome engineering in yeast, the industrially popular biomanufacturing chassis host, to produce various biocompounds. We also review progress in plant peroxisome engineering, a field that has already exhibited high potential in both biomanufacturing and agriculture. Moreover, we outline various experimentally validated strategies to improve the efficiency of engineered pathways in peroxisomes, as well as prospects of peroxisome engineering.
Competing Interests: Declaration of interests The authors declare no conflicts of interest.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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