Focal Brain Lesions Causing Acquired Amusia Map to a Common Brain Network.

Autor:	Sihvonen AJ; Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland aleksi.sihvonen@helsinki.fi.; Centre of Excellence in Music, Mind, Body and Brain, University of Helsinki, Helsinki 00014, Finland.; Queensland Aphasia Research Centre, University of Queensland, Brisbane, Queensland 4072, Australia.; Department of Neurology, Neurocenter, Helsinki University Hospital, Helsinki 00029, Finland., Ferguson MA; Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, Massachusetts 02115.; Harvard Medical School, Boston, Massachusetts 02115.; Center for the Study of World Religions, Harvard Divinity School, Cambridge, Massachusetts 02138., Chen V; Massachusetts Institute of Technology, Cambridge, Massachusetts 02139., Soinila S; Division of Clinical Neurosciences, University of Turku and Neurocenter, Turku University Hospital, Turku 20521, Finland., Särkämö T; Cognitive Brain Research Unit, Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki 00014, Finland.; Centre of Excellence in Music, Mind, Body and Brain, University of Helsinki, Helsinki 00014, Finland., Joutsa J; Turku Brain and Mind Center, Clinical Neurosciences, University of Turku, Turku 20521, Finland.; Neurocenter and Turku PET Center, Turku University Hospital, Turku 20521, Finland.
Jazyk:	angličtina
Zdroj:	The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2024 Apr 10; Vol. 44 (15). Date of Electronic Publication: 2024 Apr 10.
DOI:	10.1523/JNEUROSCI.1922-23.2024
Abstrakt:	Music is a universal human attribute. The study of amusia, a neurologic music processing deficit, has increasingly elaborated our view on the neural organization of the musical brain. However, lesions causing amusia occur in multiple brain locations and often also cause aphasia, leaving the distinct neural networks for amusia unclear. Here, we utilized lesion network mapping to identify these networks. A systematic literature search was carried out to identify all published case reports of lesion-induced amusia. The reproducibility and specificity of the identified amusia network were then tested in an independent prospective cohort of 97 stroke patients (46 female and 51 male) with repeated structural brain imaging, specifically assessed for both music perception and language abilities. Lesion locations in the case reports were heterogeneous but connected to common brain regions, including bilateral temporoparietal and insular cortices, precentral gyrus, and cingulum. In the prospective cohort, lesions causing amusia mapped to a common brain network, centering on the right superior temporal cortex and clearly distinct from the network causally associated with aphasia. Lesion-induced longitudinal structural effects in the amusia circuit were confirmed as reduction of both gray and white matter volume, which correlated with the severity of amusia. We demonstrate that despite the heterogeneity of lesion locations disrupting music processing, there is a common brain network that is distinct from the language network. These results provide evidence for the distinct neural substrate of music processing, differentiating music-related functions from language, providing a testable target for noninvasive brain stimulation to treat amusia. Competing Interests: The authors declare no competing financial interests. (Copyright © 2024 the authors.)
Databáze:	MEDLINE
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