Role of apparent diffusion map in the evaluation of retinoblastoma.

Autor:	Spadoni VS; Ophthalmology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Conceição TMBD; Radiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Schaefer FDC; Radiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Ercolani DS; Radiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Maestri MK; Ophthalmology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Klaes A; Radiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Selistre SG; Pediatric Oncology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil., Reis F; Department of Anesthesiology, Oncology and Radiology, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil., Duarte JÁ; Radiology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.; Department of Internal Medicine, Faculdade de Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Jazyk:	angličtina
Zdroj:	Arquivos brasileiros de oftalmologia [Arq Bras Oftalmol] 2024 Feb 23; Vol. 87 (2), pp. e20210435. Date of Electronic Publication: 2024 Feb 23 (Print Publication: 2024).
DOI:	10.5935/0004-2749.2021-0435
Abstrakt:	Purpose: This study aimed to analyze the association between magnetic resonance imaging apparent diffusion coefficient map value and histopathological differentiation in patients who underwent eye enucleation due to retinoblastomas. Methods: An observational chart review study of patients with retinoblastoma that had histopathology of the lesion and orbit magnetic resonance imaging with apparent diffusion coefficient analysis at Hospital de Clínicas de Porto Alegre between November 2013 and November 2016 was performed. The histopathology was reviewed after enucleation. To analyze the difference in apparent diffusion coefficient values between the two major histopathological prognostic groups, Student's t-test was used for the two groups. All statistical analyses were performed using SPSS version 19.0 for Microsoft Windows (SPSS, Inc., Chicago, IL, USA). Our institutional review board approved this retrospective study without obtaining informed consent. Results: Thirteen children were evaluated, and only eight underwent eye enucleation and were included in the analysis. The others were treated with photocoagulation, embolization, radiotherapy, and chemotherapy and were excluded due to the lack of histopathological results. When compared with histopathology, magnetic resonance imaging demonstrated 100% accuracy in retinoblastoma diagnosis. Optic nerve invasion detection on magnetic resonance imaging showed a 66.6% sensitivity and 80.0% specificity. Positive and negative predictive values were 66.6% and 80.0%, respectively, with an accuracy of 75%. In addition, the mean apparent diffusion coefficient of the eight eyes was 0.615 × 103 mm2/s. The mean apparent diffusion coefficient value of poorly or undifferentiated retinoblastoma and differentiated tumors were 0.520 × 103 mm2/s and 0.774 × 103 mm2/s, respectively. Conclusion: This study revealed that magnetic resonance imaging is useful in the diagnosis of retinoblastoma and detection of optic nerve infiltration, with a sensitivity of 66.6% and specificity of 80%. Our results also showed lower apparent diffusion coefficient values in poorly differentiated retinoblastomas with a mean of 0.520 × 103 mm2/s, whereas in well and moderately differentiated, the mean was 0.774 × 103 mm2/s.
Databáze:	MEDLINE
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