PET/CT and SPECT/CT imaging of 90Y hepatic radioembolization at therapeutic and diagnostic activity levels: Anthropomorphic phantom study.

Autor: Budzyńska A; Department of Nuclear Medicine, Military Institute of Medicine - National Research Institute, Warsaw, Poland.; Affidea Mazovian PET-CT Medical Centre, Warsaw, Poland., Kubik A; Department of Nuclear Medicine, Military Institute of Medicine - National Research Institute, Warsaw, Poland., Kacperski K; Department of Nuclear Medicine, Military Institute of Medicine - National Research Institute, Warsaw, Poland.; National Centre for Nuclear Research, Particle Acceleration Physics and Technology Division (TJ1), Otwock-Świerk, Poland., Pastusiak P; Department of Nuclear Medicine, Military Institute of Medicine - National Research Institute, Warsaw, Poland., Kuć M; National Centre for Nuclear Research, Radiological Metrology and Biomedical Physics Division (H2), Otwock-Świerk, Poland., Piasecki P; Department of Interventional Radiology, Military Institute of Medicine - National Research Institute, Warsaw, Poland., Konior M; National Centre for Nuclear Research, Radioisotope Centre POLATOM, Otwock - Świerk, Poland., Gryziński M; National Centre for Nuclear Research, Radiological Metrology and Biomedical Physics Division (H2), Otwock-Świerk, Poland., Dziuk M; Department of Nuclear Medicine, Military Institute of Medicine - National Research Institute, Warsaw, Poland.; Affidea Mazovian PET-CT Medical Centre, Warsaw, Poland., Iller E; National Centre for Nuclear Research, Radioisotope Centre POLATOM, Otwock - Świerk, Poland.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Feb 29; Vol. 19 (2), pp. e0271711. Date of Electronic Publication: 2024 Feb 29 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0271711
Abstrakt: Purpose: Prior to 90Y radioembolization procedure, a pretherapy simulation using 99mTc-MAA is performed. Alternatively, a small dosage of 90Y microspheres could be used. We aimed to assess the accuracy of lung shunt fraction (LSF) estimation in both high activity 90Y posttreatment and pretreatment scans with isotope activity of ~100 MBq, using different imaging techniques. Additionally, we assessed the feasibility of visualising hot and cold hepatic tumours in PET/CT and Bremsstrahlung SPECT/CT images.
Materials and Methods: Anthropomorphic phantom including liver (with two spherical tumours) and lung inserts was filled with 90Y chloride to simulate an LSF of 9.8%. The total initial activity in the liver was 1451 MBq, including 19.4 MBq in the hot sphere. Nine measurement sessions including PET/CT, SPECT/CT, and planar images were acquired at activities in the whole phantom ranging from 1618 MBq down to 43 MBq. The visibility of the tumours was appraised based on independent observers' scores. Quantitatively, contrast-to-noise ratio (CNR) was calculated for both spheres in all images.
Results: LSF estimation. For high activity in the phantom, PET reconstructions slightly underestimated the LSF; absolute difference was <1.5pp (percent point). For activity <100 MBq, the LSF was overestimated. Both SPECT and planar scintigraphy overestimated the LSF for all activities. Lesion visibility. For SPECT/CT, the cold tumour proved too small to be discernible (CNR <0.5) regardless of the 90Y activity in the liver, while hot sphere was visible for activity >200 MBq (CNR>4). For PET/CT, the cold tumour was only visible with the highest 90Y activity (CNR>4), whereas the hot one was seen for activity >100 MBq (CNR>5).
Conclusions: PET/CT may accurately estimate the LSF in a 90Y posttreatment procedure. However, at low activities of about 100 MBq it seems to provide unreliable estimations. PET imaging provided better visualisation of both hot and cold tumours.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Budzyńska et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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